SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jjq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		4 / 5 LEU A 268
VAL A 265
LEU A 261
GLN A 252
 None
None
None
SAH  A1406 (-4.1A)
 0.82A 1fbmE-2jjqA:
undetectable		 1fbmE-2jjqA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		4 / 5 TYR A 278
LEU A 404
THR A 371
ARG A 374
 SAH  A1406 (-4.7A)
None
None
None
 1.20A 1i2wA-2jjqA:
undetectable		 1i2wA-2jjqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1870_0
(FPRA)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		4 / 4 HIS A 107
PRO A 102
LYS A 103
ILE A 104
 None
 1.49A 1lqtA-2jjqA:
3.0		 1lqtA-2jjqA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1427_0
(FPRA)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		4 / 4 HIS A 107
PRO A 102
LYS A 103
ILE A 104
 None
 1.49A 1lquA-2jjqA:
3.2		 1lquA-2jjqA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		3 / 3 ILE A 362
ASP A 375
PHE A 372
 None
 0.62A 1uwjB-2jjqA:
undetectable		 1uwjB-2jjqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		4 / 6 ASP A 207
PHE A 206
THR A 143
GLU A 146
 None
 1.34A 2dttB-2jjqA:
undetectable
2dttC-2jjqA:
undetectable		 2dttB-2jjqA:
13.92
2dttC-2jjqA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		3 / 3 VAL A 269
VAL A 337
ASP A 318
 None
 0.52A 2fumD-2jjqA:
undetectable		 2fumD-2jjqA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 10 TYR A 364
TYR A 278
MET A 378
LEU A 350
VAL A 351
 None
SAH  A1406 (-4.7A)
None
None
None
 1.38A 2w98A-2jjqA:
6.9		 2w98A-2jjqA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 12 GLY A 180
GLU A 236
ARG A 108
PHE A 140
GLY A 106
 None
 0.98A 3ag4A-2jjqA:
0.0
3ag4B-2jjqA:
0.0
3ag4T-2jjqA:
0.0		 3ag4A-2jjqA:
19.55
3ag4B-2jjqA:
16.82
3ag4T-2jjqA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		4 / 8 ILE A 120
ALA A 147
LEU A 151
LEU A 172
 None
 0.84A 3ozwA-2jjqA:
5.2		 3ozwA-2jjqA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 10 TYR A 174
VAL A 191
SER A 212
TYR A 210
ILE A 225
 None
 1.11A 3uprA-2jjqA:
undetectable		 3uprA-2jjqA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 10 TYR A 174
VAL A 191
SER A 212
TYR A 210
ILE A 225
 None
 1.09A 3uprC-2jjqA:
undetectable		 3uprC-2jjqA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 10 TYR A 174
VAL A 191
SER A 212
TYR A 210
ILE A 225
 None
 1.09A 3vriA-2jjqA:
undetectable
3vriC-2jjqA:
undetectable		 3vriA-2jjqA:
19.95
3vriC-2jjqA:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 12 TYR A 174
VAL A 191
SER A 212
TYR A 210
ILE A 225
 None
 1.12A 3vrjA-2jjqA:
undetectable
3vrjC-2jjqA:
undetectable		 3vrjA-2jjqA:
19.95
3vrjC-2jjqA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 11 ASN A  76
ALA A  25
VAL A  57
PHE A 105
ILE A 104
 None
 1.34A 4j4vA-2jjqA:
undetectable		 4j4vA-2jjqA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		4 / 7 LYS A 193
TRP A 163
SER A 221
TYR A 222
 None
 1.23A 4l64A-2jjqA:
undetectable		 4l64A-2jjqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 12 GLY A 280
ASN A 301
SER A 325
ASP A 340
PRO A 342
 SAH  A1406 (-3.4A)
None
SAH  A1406 (-4.0A)
SAH  A1406 (-3.8A)
SAH  A1406 (-4.1A)
 0.77A 4rtpA-2jjqA:
11.5		 4rtpA-2jjqA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 11 ASP A 299
ASN A 301
SER A 325
ASP A 340
PRO A 342
 SAH  A1406 (-2.8A)
None
SAH  A1406 (-4.0A)
SAH  A1406 (-3.8A)
SAH  A1406 (-4.1A)
 0.75A 4rtrA-2jjqA:
8.9		 4rtrA-2jjqA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		6 / 12 GLY A 280
ASP A 299
ASN A 301
SER A 325
ASP A 340
PRO A 342
 SAH  A1406 (-3.4A)
SAH  A1406 (-2.8A)
None
SAH  A1406 (-4.0A)
SAH  A1406 (-3.8A)
SAH  A1406 (-4.1A)
 0.82A 4rtsA-2jjqA:
10.7		 4rtsA-2jjqA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 12 LEU A 288
VAL A 295
GLY A 282
ILE A 274
VAL A 363
 None
 0.96A 4xdrA-2jjqA:
undetectable		 4xdrA-2jjqA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		3 / 3 ARG A 110
ASP A 112
TYR A 222
 None
 0.80A 4yo9B-2jjqA:
undetectable		 4yo9B-2jjqA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		4 / 6 SER A 266
GLU A 267
ASP A 242
ARG A 237
 None
 0.99A 5cdpA-2jjqA:
undetectable
5cdpB-2jjqA:
undetectable		 5cdpA-2jjqA:
21.95
5cdpB-2jjqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		4 / 4 ASP A 276
GLY A 280
ASP A 299
ASP A 326
 None
SAH  A1406 (-3.4A)
SAH  A1406 (-2.8A)
SAH  A1406 (-3.1A)
 0.73A 5e72A-2jjqA:
16.2		 5e72A-2jjqA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 12 ASP A 340
PRO A 342
GLY A 280
THR A 283
SER A 300
 SAH  A1406 (-3.8A)
SAH  A1406 (-4.1A)
SAH  A1406 (-3.4A)
SAH  A1406 (-3.4A)
SAH  A1406 (-2.9A)
 0.97A 5hfjA-2jjqA:
3.1		 5hfjA-2jjqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 12 ASP A 340
PRO A 342
GLY A 280
THR A 283
SER A 300
 SAH  A1406 (-3.8A)
SAH  A1406 (-4.1A)
SAH  A1406 (-3.4A)
SAH  A1406 (-3.4A)
SAH  A1406 (-2.9A)
 0.95A 5hfjB-2jjqA:
2.2		 5hfjB-2jjqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 12 ASP A 340
PRO A 342
GLY A 280
THR A 283
SER A 300
 SAH  A1406 (-3.8A)
SAH  A1406 (-4.1A)
SAH  A1406 (-3.4A)
SAH  A1406 (-3.4A)
SAH  A1406 (-2.9A)
 1.08A 5hfjG-2jjqA:
2.9		 5hfjG-2jjqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 12 ASP A 340
PRO A 342
GLY A 280
THR A 283
SER A 300
 SAH  A1406 (-3.8A)
SAH  A1406 (-4.1A)
SAH  A1406 (-3.4A)
SAH  A1406 (-3.4A)
SAH  A1406 (-2.9A)
 0.88A 5hfjH-2jjqA:
3.5		 5hfjH-2jjqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		4 / 8 ILE A 209
LEU A 172
ILE A 115
TYR A 203
 None
 0.94A 5ieoA-2jjqA:
undetectable		 5ieoA-2jjqA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 10 TYR A 174
VAL A 191
SER A 212
TYR A 210
ILE A 225
 None
 1.10A 5u98A-2jjqA:
undetectable		 5u98A-2jjqA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 10 TYR A 174
VAL A 191
SER A 212
TYR A 210
ILE A 225
 None
 1.10A 5u98D-2jjqA:
undetectable		 5u98D-2jjqA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		5 / 12 MET A 277
GLY A 280
ASN A 301
ALA A 304
ASP A 326
 None
SAH  A1406 (-3.4A)
None
None
SAH  A1406 (-3.1A)
 1.10A 6b3aA-2jjqA:
10.0		 6b3aA-2jjqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780
(Pyrococcus
abyssi) 		3 / 3 VAL A 269
GLU A 270
ILE A 274
 None
 0.64A 6f7lB-2jjqA:
undetectable		 6f7lB-2jjqA:
20.37