SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jjy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 6 LEU A  73
ARG A 131
MET A 133
LEU A  84
 None
 1.06A 1v54A-2jjyA:
undetectable
1v54J-2jjyA:
undetectable		 1v54A-2jjyA:
19.53
1v54J-2jjyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 6 LEU A  73
ARG A 131
MET A 133
LEU A  84
 None
 1.03A 2eijA-2jjyA:
undetectable
2eijJ-2jjyA:
undetectable		 2eijA-2jjyA:
19.53
2eijJ-2jjyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 6 LEU A  73
ARG A 131
MET A 133
LEU A  84
 None
 1.02A 2eilA-2jjyA:
undetectable
2eilJ-2jjyA:
undetectable		 2eilA-2jjyA:
19.53
2eilJ-2jjyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 8 LEU A  73
ARG A 131
MET A 133
LEU A  84
 None
 0.92A 3abkA-2jjyA:
undetectable
3abkJ-2jjyA:
undetectable		 3abkA-2jjyA:
19.53
3abkJ-2jjyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 6 LEU A  73
ARG A 131
MET A 133
LEU A  84
 None
 1.08A 3asnA-2jjyA:
undetectable
3asnJ-2jjyA:
undetectable		 3asnA-2jjyA:
19.53
3asnJ-2jjyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 6 LEU A  73
ARG A 131
MET A 133
LEU A  84
 None
 1.07A 3asoA-2jjyA:
undetectable
3asoJ-2jjyA:
undetectable		 3asoA-2jjyA:
19.53
3asoJ-2jjyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 6 ILE A  20
TYR A  22
ILE A  11
HIS A  89
 None
 1.11A 3eteA-2jjyA:
4.3
3eteE-2jjyA:
4.2		 3eteA-2jjyA:
20.97
3eteE-2jjyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 5 ILE A  20
TYR A  22
ILE A  11
HIS A  89
 None
 1.09A 3eteB-2jjyA:
4.2
3eteC-2jjyA:
4.6		 3eteB-2jjyA:
20.97
3eteC-2jjyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 7 ILE A  11
HIS A  89
ILE A  20
TYR A  22
 None
 1.11A 3eteD-2jjyA:
4.4
3eteF-2jjyA:
4.2		 3eteD-2jjyA:
20.97
3eteF-2jjyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		5 / 10 LEU A 232
GLY A 239
ASN A 138
GLY A 178
VAL A 142
 None
 0.89A 3lzvA-2jjyA:
undetectable		 3lzvA-2jjyA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		3 / 3 ASP A  97
GLU A 110
GLY A 111
 None
 0.69A 3w9tA-2jjyA:
undetectable		 3w9tA-2jjyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		5 / 12 ILE A 192
GLU A 150
TYR A 251
HIS A 246
VAL A 220
 None
 1.22A 4a97B-2jjyA:
undetectable
4a97C-2jjyA:
undetectable		 4a97B-2jjyA:
21.99
4a97C-2jjyA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 8 ILE A  87
ILE A  70
LYS A  79
GLY A  78
 None
 0.80A 4hdlA-2jjyA:
undetectable		 4hdlA-2jjyA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		5 / 12 LEU A 144
THR A  12
ALA A  21
ILE A 222
ILE A  24
 None
 0.99A 5itzB-2jjyA:
7.4		 5itzB-2jjyA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 5 LEU A  60
PHE A  37
LEU A  73
PHE A  74
 None
 1.20A 5iy5P-2jjyA:
undetectable
5iy5W-2jjyA:
undetectable		 5iy5P-2jjyA:
20.95
5iy5W-2jjyA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 7 LEU A   4
ALA A  27
ILE A  11
LEU A  35
 None
 0.95A 5te8C-2jjyA:
undetectable		 5te8C-2jjyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 6 LEU A  60
PHE A  37
LEU A  73
PHE A  74
 None
 1.12A 5w97C-2jjyA:
undetectable
5w97J-2jjyA:
undetectable		 5w97C-2jjyA:
21.14
5w97J-2jjyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 5 LEU A  60
PHE A  37
LEU A  73
PHE A  74
 None
 1.19A 5x1fC-2jjyA:
undetectable
5x1fJ-2jjyA:
undetectable		 5x1fC-2jjyA:
21.14
5x1fJ-2jjyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 5 LEU A  60
PHE A  37
LEU A  73
PHE A  74
 None
 1.21A 5xdxC-2jjyA:
undetectable
5xdxJ-2jjyA:
undetectable		 5xdxC-2jjyA:
20.88
5xdxJ-2jjyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 5 LEU A  60
PHE A  37
LEU A  73
PHE A  74
 None
 1.18A 5xdxP-2jjyA:
undetectable
5xdxW-2jjyA:
undetectable		 5xdxP-2jjyA:
20.88
5xdxW-2jjyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		5 / 12 LEU A 144
THR A  12
ALA A  21
ILE A 222
ILE A  24
 None
 0.96A 5xiwB-2jjyA:
6.6		 5xiwB-2jjyA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 6 LEU A  84
ALA A  86
LEU A  73
THR A  38
 None
 0.93A 6f88B-2jjyA:
undetectable		 6f88B-2jjyA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
(Francisella
tularensis) 		4 / 5 THR A 158
CYH A 106
THR A 108
GLY A 111
 None
 1.26A 6gtqA-2jjyA:
undetectable		 6gtqA-2jjyA:
22.08