SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jjz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		5 / 8 ILE B  67
LEU B  72
MET B  91
GLU B  94
MET B 111
 None
 0.53A 1a29A-2jjzB:
8.8		 1a29A-2jjzB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		5 / 9 ILE B  67
LEU B  72
MET B  91
GLU B  94
MET B 111
 None
 0.70A 1ctrA-2jjzB:
7.8		 1ctrA-2jjzB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		8 / 11 PHE B  59
ILE B  67
LEU B  72
MET B  76
LEU B  79
MET B  91
VAL B  95
MET B 111
 None
 0.75A 1dtlA-2jjzB:
8.9		 1dtlA-2jjzB:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		5 / 8 ILE B  67
LEU B  72
MET B  88
ILE B  92
ILE B 103
 None
 1.42A 1linA-2jjzB:
8.8		 1linA-2jjzB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		8 / 8 ILE B  67
LEU B  72
MET B  91
ILE B  92
GLU B  94
VAL B  95
ILE B 103
MET B 111
 None
 0.75A 1linA-2jjzB:
8.8		 1linA-2jjzB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		6 / 12 ILE B  67
LEU B  72
MET B  76
LEU B  79
ILE B  92
MET B 111
 None
 1.08A 1lxfC-2jjzB:
7.2		 1lxfC-2jjzB:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		7 / 12 ILE B  67
LEU B  72
MET B  76
LEU B  79
MET B  91
ILE B  92
GLU B  94
 None
 0.94A 1lxfC-2jjzB:
7.2		 1lxfC-2jjzB:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		6 / 12 PHE B  59
ILE B  67
LEU B  72
MET B  76
ILE B  92
MET B 111
 None
 1.11A 1lxfC-2jjzB:
7.2		 1lxfC-2jjzB:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		7 / 12 PHE B  59
ILE B  67
LEU B  72
MET B  76
MET B  91
ILE B  92
GLU B  94
 None
 0.99A 1lxfC-2jjzB:
7.2		 1lxfC-2jjzB:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		4 / 8 LEU B  72
LEU B  79
GLY B  80
MET B  88
 None
 0.86A 1n13A-2jjzB:
undetectable
1n13F-2jjzB:
undetectable		 1n13A-2jjzB:
23.66
1n13F-2jjzB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		4 / 7 LEU B  72
LEU B  79
GLY B  80
MET B  88
 None
 0.87A 1n13G-2jjzB:
undetectable
1n13J-2jjzB:
undetectable		 1n13G-2jjzB:
23.66
1n13J-2jjzB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		4 / 5 PHE B  59
LEU B  79
PHE B 108
MET B 112
 None
 1.22A 1wrlC-2jjzB:
8.3		 1wrlC-2jjzB:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		4 / 7 PHE B  52
LEU B  79
PHE B 108
MET B 112
 None
 1.12A 1wrlE-2jjzB:
8.3		 1wrlE-2jjzB:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		5 / 11 LEU B  61
ILE B  67
LEU B 120
ARG B  74
LYS B  73
 None
 1.30A 2bxmA-2jjzB:
2.1		 2bxmA-2jjzB:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		4 / 8 MET B  88
LEU B  72
LEU B  79
GLY B  80
 None
 0.87A 2qqcH-2jjzB:
undetectable
2qqcK-2jjzB:
undetectable		 2qqcH-2jjzB:
22.06
2qqcK-2jjzB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		4 / 8 MET B  88
LEU B  72
LEU B  79
GLY B  80
 None
 0.84A 2qqdB-2jjzB:
undetectable
2qqdC-2jjzB:
undetectable		 2qqdB-2jjzB:
22.06
2qqdC-2jjzB:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		4 / 8 ILE B  67
LEU B  72
MET B  76
MET B 111
 None
 0.70A 4rjdA-2jjzB:
8.0		 4rjdA-2jjzB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		4 / 8 ILE B  67
LEU B  72
MET B  91
MET B 111
 None
 0.64A 4rjdA-2jjzB:
8.0		 4rjdA-2jjzB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		4 / 7 LEU B  72
MET B  76
MET B 111
MET B 112
 None
 0.83A 4rjdB-2jjzB:
7.8		 4rjdB-2jjzB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		5 / 7 PHE B  59
LEU B  72
MET B  91
MET B 111
MET B 112
 None
 0.95A 4rjdB-2jjzB:
7.8		 4rjdB-2jjzB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens) 		5 / 10 LEU B  72
MET B  91
VAL B  95
ILE B 103
MET B 112
 None
 0.53A 5v02B-2jjzB:
undetectable
5v02R-2jjzB:
4.7		 5v02B-2jjzB:
19.75
5v02R-2jjzB:
21.28