SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jk0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		5 / 10 ASP A 260
GLY A 259
VAL A 255
ARG A 264
GLY A 262
 None
 1.50A 1fohA-2jk0A:
undetectable		 1fohA-2jk0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		5 / 10 ASP A 260
GLY A 259
VAL A 255
ARG A 264
GLY A 262
 None
 1.48A 1fohB-2jk0A:
undetectable		 1fohB-2jk0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		5 / 10 ASP A 260
GLY A 259
VAL A 255
ARG A 264
GLY A 262
 None
 1.49A 1fohD-2jk0A:
undetectable		 1fohD-2jk0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		4 / 6 ILE A 188
LYS A 140
ALA A 142
VAL A 155
 None
 0.98A 1hk1A-2jk0A:
undetectable		 1hk1A-2jk0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		3 / 3 ASP A 215
ASP A  68
LYS A  75
 None
 1.12A 1lqtB-2jk0A:
2.1		 1lqtB-2jk0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		3 / 3 ASP A 215
ASP A  68
LYS A  75
 None
 1.12A 1lquB-2jk0A:
undetectable		 1lquB-2jk0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		4 / 7 LEU A  73
GLY A  14
ILE A  16
VAL A  57
 None
ASP  A1328 (-3.2A)
None
None
 0.77A 2aojB-2jk0A:
undetectable		 2aojB-2jk0A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		3 / 3 VAL A 242
VAL A 272
ASP A 229
 None
 0.77A 2fumD-2jk0A:
undetectable		 2fumD-2jk0A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		3 / 3 HIS A  93
ILE A  16
LEU A 156
 None
 0.67A 2kceA-2jk0A:
undetectable		 2kceA-2jk0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		4 / 8 ASN A 134
ILE A 166
VAL A 187
TYR A 184
 None
 0.74A 2yoeB-2jk0A:
undetectable
2yoeC-2jk0A:
undetectable		 2yoeB-2jk0A:
21.63
2yoeC-2jk0A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		3 / 3 GLY A 225
GLY A 251
GLY A 249
 None
 0.33A 3bogC-2jk0A:
undetectable		 3bogC-2jk0A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		5 / 10 LEU A  73
ASN A  64
GLY A  14
ILE A  16
VAL A  57
 None
None
ASP  A1328 (-3.2A)
None
None
 0.87A 3lzvA-2jk0A:
undetectable		 3lzvA-2jk0A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		5 / 12 TYR A 226
VAL A 255
SER A 256
ARG A 258
VAL A 273
 None
 1.16A 3vt7A-2jk0A:
undetectable		 3vt7A-2jk0A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		3 / 3 ASP A 130
ARG A 122
ASP A 175
 None
 0.85A 4fp9D-2jk0A:
undetectable		 4fp9D-2jk0A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		3 / 3 ASP A 130
ARG A 122
ASP A 175
 None
 0.76A 4fzvA-2jk0A:
undetectable		 4fzvA-2jk0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		3 / 3 VAL A 115
GLY A  88
LYS A 113
 None
 0.78A 4k50E-2jk0A:
undetectable		 4k50E-2jk0A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		5 / 11 SER A 299
LEU A 156
VAL A 154
ASP A 130
MET A 121
 None
None
None
None
ASP  A1328 ( 4.3A)
 1.48A 4pghC-2jk0A:
undetectable		 4pghC-2jk0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		6 / 12 LYS A  75
VAL A  77
ASN A  78
ALA A  82
VAL A 115
ILE A  91
 None
 1.46A 5j2tC-2jk0A:
undetectable		 5j2tC-2jk0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		5 / 12 LEU A  49
LEU A 135
ILE A   7
ALA A  50
ILE A   9
 None
 0.89A 5nm5B-2jk0A:
2.2		 5nm5B-2jk0A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		3 / 3 ASP A 130
ARG A 122
ASP A 175
 None
 0.80A 5zvgA-2jk0A:
undetectable		 5zvgA-2jk0A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		3 / 3 ASP A 130
ARG A 122
ASP A 175
 None
 0.80A 5zvgB-2jk0A:
undetectable		 5zvgB-2jk0A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		5 / 12 ALA A  42
PHE A 177
VAL A 154
HIS A  93
LEU A  34
 None
 1.04A 6djzC-2jk0A:
undetectable		 6djzC-2jk0A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2jk0 L-ASPARAGINASE
(Pectobacterium
carotovorum) 		4 / 7 SER A 299
PHE A 324
VAL A 211
LEU A 309
 None
 0.81A 6dwnB-2jk0A:
undetectable		 6dwnB-2jk0A:
14.29