SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2jk1 HYDROGENASE
TRANSCRIPTIONAL
REGULATORY PROTEIN
HUPR1
(Rhodobacter
capsulatus) 		5 / 8 LEU A  44
ALA A  40
LEU A  67
GLY A  63
ASP A  65
 None
 1.36A 2yfxA-2jk1A:
undetectable		 2yfxA-2jk1A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 2jk1 HYDROGENASE
TRANSCRIPTIONAL
REGULATORY PROTEIN
HUPR1
(Rhodobacter
capsulatus) 		4 / 4 PRO A  75
THR A  77
GLY A  63
THR A  62
 None
 1.18A 3ib1A-2jk1A:
2.5		 3ib1A-2jk1A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 2jk1 HYDROGENASE
TRANSCRIPTIONAL
REGULATORY PROTEIN
HUPR1
(Rhodobacter
capsulatus) 		4 / 4 ILE A   8
GLN A  50
VAL A  51
PHE A  29
 None
 1.47A 3ieoA-2jk1A:
0.0		 3ieoA-2jk1A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 2jk1 HYDROGENASE
TRANSCRIPTIONAL
REGULATORY PROTEIN
HUPR1
(Rhodobacter
capsulatus) 		3 / 3 PRO A   6
PHE A  29
ALA A 121
 None
 0.62A 3itaD-2jk1A:
undetectable		 3itaD-2jk1A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2jk1 HYDROGENASE
TRANSCRIPTIONAL
REGULATORY PROTEIN
HUPR1
(Rhodobacter
capsulatus) 		4 / 5 ARG A  57
ASP A  13
ASP A  55
ASP A  12
 None
MG  A1144 (-2.4A)
MG  A1144 (-2.8A)
MG  A1144 ( 4.6A)
 1.33A 3naiC-2jk1A:
undetectable		 3naiC-2jk1A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 2jk1 HYDROGENASE
TRANSCRIPTIONAL
REGULATORY PROTEIN
HUPR1
(Rhodobacter
capsulatus) 		5 / 12 ILE A  52
LEU A  44
ILE A  41
ALA A  40
ILE A 100
 None
 1.07A 3vrmA-2jk1A:
undetectable		 3vrmA-2jk1A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2jk1 HYDROGENASE
TRANSCRIPTIONAL
REGULATORY PROTEIN
HUPR1
(Rhodobacter
capsulatus) 		4 / 8 ILE A 100
SER A 116
LEU A  10
ILE A  52
 None
 0.94A 4xtaB-2jk1A:
undetectable		 4xtaB-2jk1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2jk1 HYDROGENASE
TRANSCRIPTIONAL
REGULATORY PROTEIN
HUPR1
(Rhodobacter
capsulatus) 		5 / 10 GLY A  63
ALA A  94
VAL A  64
ASP A  55
ILE A  81
 None
None
None
MG  A1144 (-2.8A)
None
 1.11A 5i3cB-2jk1A:
2.8		 5i3cB-2jk1A:
20.83