SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jk9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2jk9 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 1
(Homo
sapiens) 		4 / 6 ASP A 143
LEU A 144
ILE A 172
TRP A 104
 None
 0.95A 1s9qA-2jk9A:
undetectable		 1s9qA-2jk9A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 2jk9 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 1
(Homo
sapiens) 		4 / 7 ASN A 136
GLY A 134
THR A 131
SER A 126
 None
 1.18A 2o5yH-2jk9A:
undetectable
2o5yL-2jk9A:
undetectable		 2o5yH-2jk9A:
21.98
2o5yL-2jk9A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2jk9 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 178
ALA A 180
LEU A  97
MET A  43
 None
 1.10A 2oaxA-2jk9A:
undetectable		 2oaxA-2jk9A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA156_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 2jk9 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 1
(Homo
sapiens) 		4 / 7 THR A 119
TRP A 140
MET A 183
LEU A 181
 None
 1.33A 2rezA-2jk9A:
0.0		 2rezA-2jk9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 2jk9 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 1
(Homo
sapiens) 		4 / 6 ARG A  88
ALA A  86
ASP A  60
LEU A 132
 None
 1.11A 4ot2A-2jk9A:
undetectable		 4ot2A-2jk9A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 2jk9 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 209
ALA A 118
LEU A 188
MET A 224
ILE A 102
 None
 1.17A 5gs4A-2jk9A:
undetectable		 5gs4A-2jk9A:
20.24