SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jkd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 2jkd PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 198
THR A 165
LEU A 188
LEU A 186
 None
 1.00A 1u18B-2jkdA:
undetectable		 1u18B-2jkdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2jkd PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  80
TYR A  96
ILE A  82
GLY A 107
 None
 0.94A 2du8A-2jkdA:
undetectable		 2du8A-2jkdA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2jkd PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 201
LEU A 180
ILE A 172
PRO A 173
LEU A 186
 None
 1.16A 3nrrA-2jkdA:
undetectable		 3nrrA-2jkdA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2jkd PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 SER A 189
GLY A 164
THR A 165
SER A 136
THR A 135
 None
 1.46A 3r75B-2jkdA:
undetectable		 3r75B-2jkdA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2jkd PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 186
LEU A 167
PRO A 173
ILE A 172
 None
 0.75A 3s56B-2jkdA:
undetectable		 3s56B-2jkdA:
23.38