SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2jks BRADYZOITE SURFACE
ANTIGEN BSR4
(Toxoplasma
gondii) 		4 / 8 VAL A 174
VAL A 307
VAL A 305
LEU A 198
 None
 0.78A 1igxA-2jksA:
undetectable		 1igxA-2jksA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2jks BRADYZOITE SURFACE
ANTIGEN BSR4
(Toxoplasma
gondii) 		3 / 3 PHE A 134
LEU A 120
LEU A 122
 None
 0.64A 1mx1E-2jksA:
undetectable		 1mx1E-2jksA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2jks BRADYZOITE SURFACE
ANTIGEN BSR4
(Toxoplasma
gondii) 		4 / 8 ALA A  81
GLY A  80
GLN A 139
THR A 152
 None
 0.94A 3rglA-2jksA:
undetectable		 3rglA-2jksA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2jks BRADYZOITE SURFACE
ANTIGEN BSR4
(Toxoplasma
gondii) 		5 / 12 GLY A 206
SER A 204
ILE A 200
ASN A 201
GLY A 274
 None
ZN  A1320 ( 4.9A)
None
None
None
 1.18A 4obwA-2jksA:
undetectable		 4obwA-2jksA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 2jks BRADYZOITE SURFACE
ANTIGEN BSR4
(Toxoplasma
gondii) 		3 / 3 ALA A 255
TRP A 245
VAL A 246
 None
 0.23A 4w9nC-2jksA:
undetectable		 4w9nC-2jksA:
23.82