SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jky'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A  67
GLU A 194
TYR A 191
SER A  74
 MG  A 302 ( 3.8A)
5GP  A 300 (-2.7A)
5GP  A 300 (-4.6A)
None
 1.18A 1vidA-2jkyA:
3.5		 1vidA-2jkyA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  71
ILE A   9
VAL A 155
 None
 0.70A 2avvD-2jkyA:
undetectable		 2avvD-2jkyA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A  67
GLU A 194
TYR A 191
SER A  74
 MG  A 302 ( 3.8A)
5GP  A 300 (-2.7A)
5GP  A 300 (-4.6A)
None
 1.19A 2cl5B-2jkyA:
4.0		 2cl5B-2jkyA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  32
ILE A  34
ILE A 108
ALA A 122
PHE A  28
 None
 1.16A 2gj5A-2jkyA:
undetectable		 2gj5A-2jkyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 5 PRO A  43
TYR A  11
TYR A 191
PRO A 192
 None
None
5GP  A 300 (-4.6A)
None
 1.26A 2ombA-2jkyA:
undetectable
2ombB-2jkyA:
undetectable		 2ombA-2jkyA:
22.45
2ombB-2jkyA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  66
ILE A  36
GLY A  37
GLY A  38
LEU A  68
 None
None
SO4  A 301 ( 4.1A)
SO4  A 301 (-3.2A)
None
 1.20A 2qmmA-2jkyA:
undetectable		 2qmmA-2jkyA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A  67
GLU A 194
TYR A 191
SER A  74
 MG  A 302 ( 3.8A)
5GP  A 300 (-2.7A)
5GP  A 300 (-4.6A)
None
 1.22A 2zvjA-2jkyA:
4.1		 2zvjA-2jkyA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 159
VAL A 112
HIS A 157
 5GP  A 300 (-2.9A)
5GP  A 300 (-4.9A)
None
 0.95A 3tj7A-2jkyA:
undetectable		 3tj7A-2jkyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 4 ALA A 180
VAL A 155
ASP A 158
LEU A 119
 None
 1.36A 4e7gA-2jkyA:
undetectable		 4e7gA-2jkyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 178
LEU A 167
ALA A 122
ALA A 165
THR A 117
 None
None
None
None
5GP  A 300 (-3.7A)
 1.19A 4fiaA-2jkyA:
undetectable		 4fiaA-2jkyA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 178
LEU A 167
ALA A 122
ALA A 165
THR A 117
 None
None
None
None
5GP  A 300 (-3.7A)
 1.19A 4fiaA-2jkyA:
undetectable		 4fiaA-2jkyA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 109
ILE A  46
LEU A  47
ALA A 181
LEU A 156
 None
 1.15A 4m11D-2jkyA:
undetectable		 4m11D-2jkyA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 5 ASP A  71
VAL A 112
ASP A 110
GLY A  39
 None
5GP  A 300 (-4.9A)
5GP  A 300 (-3.4A)
None
 1.03A 4xp6A-2jkyA:
undetectable		 4xp6A-2jkyA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  38
GLY A  37
ALA A  35
ILE A  65
 SO4  A 301 (-3.2A)
SO4  A 301 ( 4.1A)
None
None
 0.71A 4yjiA-2jkyA:
undetectable		 4yjiA-2jkyA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A  67
GLU A 194
TYR A 191
SER A  74
 MG  A 302 ( 3.8A)
5GP  A 300 (-2.7A)
5GP  A 300 (-4.6A)
None
 1.19A 5fhrA-2jkyA:
undetectable		 5fhrA-2jkyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  47
PHE A 154
LEU A 156
HIS A  15
 None
 1.02A 5gtrA-2jkyA:
undetectable		 5gtrA-2jkyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 107
PHE A 154
VAL A 109
ALA A  63
ALA A  35
 None
 1.14A 5tzoB-2jkyA:
undetectable		 5tzoB-2jkyA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 154
ASP A 110
LEU A  99
 None
5GP  A 300 (-3.4A)
None
 0.76A 5uhbC-2jkyA:
undetectable		 5uhbC-2jkyA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 154
ASP A 110
LEU A 101
 None
5GP  A 300 (-3.4A)
None
 0.80A 5uhbC-2jkyA:
undetectable		 5uhbC-2jkyA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  37
VAL A 112
GLY A  39
GLY A  40
PRO A  43
 SO4  A 301 ( 4.1A)
5GP  A 300 (-4.9A)
None
None
None
 1.02A 5wyqA-2jkyA:
undetectable		 5wyqA-2jkyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 6 GLN A   7
HIS A 201
ALA A 205
GLN A 208
 None
 1.07A 6f6jC-2jkyA:
undetectable
6f6jD-2jkyA:
undetectable		 6f6jC-2jkyA:
19.95
6f6jD-2jkyA:
19.95