SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jl4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2jl4 MALEYLPYRUVATE
ISOMERASE
(Ralstonia
sp.
U2) 		5 / 12 GLY A 137
PHE A 138
LEU A 145
ILE A  98
LEU A  95
 None
 1.07A 1lhuA-2jl4A:
undetectable		 1lhuA-2jl4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 2jl4 MALEYLPYRUVATE
ISOMERASE
(Ralstonia
sp.
U2) 		5 / 12 SER A   9
LEU A  33
PHE A  43
ASN A  47
ALA A  54
 GSH  A1213 (-3.0A)
GSH  A1213 ( 4.4A)
None
None
None
 1.38A 3nuvA-2jl4A:
undetectable		 3nuvA-2jl4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2jl4 MALEYLPYRUVATE
ISOMERASE
(Ralstonia
sp.
U2) 		5 / 11 TYR A 154
GLY A 157
ASP A 164
GLY A  88
ALA A  94
 None
 1.17A 3sufC-2jl4A:
undetectable		 3sufC-2jl4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2jl4 MALEYLPYRUVATE
ISOMERASE
(Ralstonia
sp.
U2) 		4 / 6 ARG A  14
LEU A  51
PRO A  53
SER A  65
 GSH  A1213 (-4.2A)
GSH  A1213 (-3.6A)
GSH  A1213 ( 4.7A)
GSH  A1213 (-2.7A)
 0.85A 3vlnA-2jl4A:
19.4		 3vlnA-2jl4A:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2jl4 MALEYLPYRUVATE
ISOMERASE
(Ralstonia
sp.
U2) 		5 / 12 LEU A 162
ASP A 164
CYH A 194
ALA A 199
THR A 159
 None
 1.37A 4iaqA-2jl4A:
2.4		 4iaqA-2jl4A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2jl4 MALEYLPYRUVATE
ISOMERASE
(Ralstonia
sp.
U2) 		5 / 12 LEU A 162
ASP A 164
CYH A 194
ALA A 199
THR A 159
 None
 1.38A 4iarA-2jl4A:
2.2		 4iarA-2jl4A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 2jl4 MALEYLPYRUVATE
ISOMERASE
(Ralstonia
sp.
U2) 		4 / 8 PRO A  83
PHE A 156
SER A 155
TYR A 141
 None
 1.38A 5amiB-2jl4A:
undetectable		 5amiB-2jl4A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 2jl4 MALEYLPYRUVATE
ISOMERASE
(Ralstonia
sp.
U2) 		5 / 12 LEU A 144
ALA A 146
LEU A 186
ILE A  98
LEU A 167
 None
 0.90A 5toaA-2jl4A:
undetectable		 5toaA-2jl4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 2jl4 MALEYLPYRUVATE
ISOMERASE
(Ralstonia
sp.
U2) 		5 / 12 ALA A  80
TYR A  26
MET A   1
ALA A  54
LEU A  15
 None
 1.23A 6aycA-2jl4A:
undetectable		 6aycA-2jl4A:
17.68