SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D1G_B_MTXB171_1 (DIHYDROFOLATE REDUCTASE)	2jn4	HYPOTHETICAL PROTEIN FIXU, NIFT (Rhodopseudomonas palustris)	5 / 12	VAL A 61 ALA A 63 ILE A 25 LEU A 33 ILE A 5	None	1.09A	1d1gB-2jn4A: undetectable	1d1gB-2jn4A: 20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CLB_C_TMQC613_1 (DHFR-TS)	2jn4	HYPOTHETICAL PROTEIN FIXU, NIFT (Rhodopseudomonas palustris)	5 / 12	VAL A 61 ALA A 63 ILE A 25 LEU A 33 ILE A 5	None	1.04A	3clbC-2jn4A: undetectable	3clbC-2jn4A: 8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HBB_A_TMQA611_1 (DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2jn4	HYPOTHETICAL PROTEIN FIXU, NIFT (Rhodopseudomonas palustris)	5 / 10	VAL A 61 ALA A 63 ILE A 25 LEU A 33 ILE A 5	None	1.08A	3hbbA-2jn4A: undetectable	3hbbA-2jn4A: 8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HBB_C_TMQC613_1 (DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2jn4	HYPOTHETICAL PROTEIN FIXU, NIFT (Rhodopseudomonas palustris)	5 / 11	VAL A 61 ALA A 63 ILE A 25 LEU A 33 ILE A 5	None	1.08A	3hbbC-2jn4A: undetectable	3hbbC-2jn4A: 8.86

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1D1G_B_MTXB171_1","DIHYDROFOLATE REDUCTASE","2jn4","HYPOTHETICAL PROTEIN FIXU, NIFT","Rhodopseudomonas palustris",5,"VAL A  61;ALA A  63;ILE A  25;LEU A  33;ILE A   5","None","1.09A","1d1gB-2jn4A:undetectable","1d1gB-2jn4A:20.25"],["3CLB_C_TMQC613_1","DHFR-TS","2jn4","HYPOTHETICAL PROTEIN FIXU, NIFT","Rhodopseudomonas palustris",5,"VAL A  61;ALA A  63;ILE A  25;LEU A  33;ILE A   5","None","1.04A","3clbC-2jn4A:undetectable","3clbC-2jn4A:8.86"],["3HBB_A_TMQA611_1","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","2jn4","HYPOTHETICAL PROTEIN FIXU, NIFT","Rhodopseudomonas palustris",5,"VAL A  61;ALA A  63;ILE A  25;LEU A  33;ILE A   5","None","1.08A","3hbbA-2jn4A:undetectable","3hbbA-2jn4A:8.86"],["3HBB_C_TMQC613_1","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","2jn4","HYPOTHETICAL PROTEIN FIXU, NIFT","Rhodopseudomonas palustris",5,"VAL A  61;ALA A  63;ILE A  25;LEU A  33;ILE A   5","None","1.08A","3hbbC-2jn4A:undetectable","3hbbC-2jn4A:8.86"]]