SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jok'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		4 / 7 ALA A 117
THR A 118
ALA A 121
ARG A 207
 None
 0.87A 2ql8A-2jokA:
undetectable
2ql8B-2jokA:
undetectable		 2ql8A-2jokA:
20.00
2ql8B-2jokA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		5 / 11 ARG A 129
LEU A 119
PHE A 229
ARG A 142
LEU A 149
 None
 1.34A 2v0mD-2jokA:
1.8		 2v0mD-2jokA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		5 / 11 GLU A 180
LEU A 177
VAL A  96
ILE A 104
LEU A 213
 None
 1.23A 3fl9C-2jokA:
undetectable		 3fl9C-2jokA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		4 / 8 GLY A 171
MET A 132
CYH A 131
PHE A 130
 None
 0.96A 3ko0B-2jokA:
0.0
3ko0J-2jokA:
undetectable		 3ko0B-2jokA:
17.20
3ko0J-2jokA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		4 / 8 GLY A 171
MET A 132
CYH A 131
PHE A 130
 None
 1.08A 3ko0B-2jokA:
undetectable
3ko0J-2jokA:
undetectable		 3ko0B-2jokA:
17.20
3ko0J-2jokA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		4 / 8 GLY A 173
MET A 132
CYH A 131
PHE A 130
 None
 1.10A 3ko0B-2jokA:
undetectable
3ko0J-2jokA:
undetectable		 3ko0B-2jokA:
17.20
3ko0J-2jokA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		4 / 8 GLY A 171
MET A 132
CYH A 131
PHE A 130
 None
 1.05A 3ko0K-2jokA:
undetectable
3ko0S-2jokA:
undetectable		 3ko0K-2jokA:
17.20
3ko0S-2jokA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		4 / 7 GLY A 171
MET A 132
CYH A 131
PHE A 130
 None
 1.05A 3ko0L-2jokA:
undetectable
3ko0N-2jokA:
undetectable		 3ko0L-2jokA:
17.20
3ko0N-2jokA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		4 / 7 GLY A 173
MET A 132
CYH A 131
PHE A 130
 None
 1.13A 3ko0L-2jokA:
undetectable
3ko0N-2jokA:
undetectable		 3ko0L-2jokA:
17.20
3ko0N-2jokA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		4 / 7 GLY A 171
MET A 132
CYH A 131
PHE A 130
 None
 1.07A 3ko0K-2jokA:
undetectable
3ko0S-2jokA:
undetectable		 3ko0K-2jokA:
17.20
3ko0S-2jokA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		4 / 7 GLY A 173
MET A 132
CYH A 131
PHE A 130
 None
 1.08A 3ko0K-2jokA:
undetectable
3ko0S-2jokA:
undetectable		 3ko0K-2jokA:
17.20
3ko0S-2jokA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		4 / 7 GLY A 171
MET A 132
CYH A 131
PHE A 130
 None
 0.97A 3ko0R-2jokA:
undetectable
3ko0T-2jokA:
undetectable		 3ko0R-2jokA:
17.20
3ko0T-2jokA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		4 / 7 GLY A 173
MET A 132
CYH A 131
PHE A 130
 None
 1.07A 3ko0R-2jokA:
undetectable
3ko0T-2jokA:
undetectable		 3ko0R-2jokA:
17.20
3ko0T-2jokA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		4 / 8 THR A 179
LEU A 177
ALA A 117
ALA A 121
 None
 0.89A 3ns1L-2jokA:
undetectable		 3ns1L-2jokA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		3 / 3 TYR A 205
LEU A 236
ARG A 207
 None
 0.79A 3sufB-2jokA:
undetectable		 3sufB-2jokA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		5 / 12 GLY A 160
ARG A 207
GLY A 150
ALA A 153
PHE A 229
 None
 1.09A 3sugA-2jokA:
undetectable		 3sugA-2jokA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		5 / 9 LEU A 119
ALA A 152
ASP A 151
VAL A 233
LEU A 236
 None
 1.34A 3wsjA-2jokA:
undetectable		 3wsjA-2jokA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		4 / 6 ALA A  84
GLN A  83
LEU A 193
LEU A 202
 None
 1.16A 4xoyA-2jokA:
undetectable		 4xoyA-2jokA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR
(Burkholderia
pseudomallei) 		4 / 6 ALA A  84
GLN A  83
LEU A 193
LEU A 202
 None
 1.16A 4xp3A-2jokA:
undetectable		 4xp3A-2jokA:
18.18