SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jp2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 ILE A  61
LEU A  60
LEU A  73
GLU A  74
 None
 0.84A 1eupA-2jp2A:
undetectable		 1eupA-2jp2A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 9 VAL A  45
VAL A  43
GLY A  44
LEU A  81
TYR A  83
 None
 1.15A 1lwfA-2jp2A:
undetectable		 1lwfA-2jp2A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 TYR A  83
GLY A 101
VAL A  43
LYS A  99
PHE A  90
 None
 1.18A 1nw3A-2jp2A:
undetectable		 1nw3A-2jp2A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 HIS A  92
TRP A  32
ASP A  96
HIS A  91
 None
 1.49A 1v54A-2jp2A:
undetectable
1v54C-2jp2A:
undetectable		 1v54A-2jp2A:
13.64
1v54C-2jp2A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 HIS A  92
TRP A  32
ASP A  96
HIS A  91
 None
 1.47A 1v55A-2jp2A:
undetectable
1v55C-2jp2A:
undetectable		 1v55A-2jp2A:
13.64
1v55C-2jp2A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 HIS A  92
TRP A  32
ASP A  96
HIS A  91
 None
 1.49A 2dyrA-2jp2A:
undetectable
2dyrC-2jp2A:
undetectable		 2dyrA-2jp2A:
13.64
2dyrC-2jp2A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 HIS A  92
TRP A  32
ASP A  96
HIS A  91
 None
 1.48A 2eijA-2jp2A:
undetectable
2eijC-2jp2A:
undetectable		 2eijA-2jp2A:
13.64
2eijC-2jp2A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 HIS A  92
TRP A  32
ASP A  96
HIS A  91
 None
 1.47A 2eikA-2jp2A:
undetectable
2eikC-2jp2A:
undetectable		 2eikA-2jp2A:
13.64
2eikC-2jp2A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 HIS A  92
TRP A  32
ASP A  96
HIS A  91
 None
 1.49A 2eikN-2jp2A:
undetectable
2eikP-2jp2A:
undetectable		 2eikN-2jp2A:
13.64
2eikP-2jp2A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 HIS A  92
TRP A  32
ASP A  96
HIS A  91
 None
 1.48A 2eilA-2jp2A:
undetectable
2eilC-2jp2A:
undetectable		 2eilA-2jp2A:
13.64
2eilC-2jp2A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		3 / 3 GLN A  66
LYS A  19
VAL A  43
 None
 0.93A 2jfaB-2jp2A:
undetectable		 2jfaB-2jp2A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 HIS A  92
TRP A  32
ASP A  96
HIS A  91
 None
 1.49A 3abkA-2jp2A:
undetectable
3abkC-2jp2A:
undetectable		 3abkA-2jp2A:
13.64
3abkC-2jp2A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 HIS A  92
TRP A  32
ASP A  96
HIS A  91
 None
 1.47A 3abkN-2jp2A:
undetectable
3abkP-2jp2A:
undetectable		 3abkN-2jp2A:
13.64
3abkP-2jp2A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 HIS A  92
TRP A  32
ASP A  96
HIS A  91
 None
 1.49A 3ag2A-2jp2A:
undetectable
3ag2C-2jp2A:
undetectable		 3ag2A-2jp2A:
13.64
3ag2C-2jp2A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 HIS A  92
TRP A  32
ASP A  96
HIS A  91
 None
 1.50A 3ag4A-2jp2A:
undetectable
3ag4C-2jp2A:
undetectable		 3ag4A-2jp2A:
13.64
3ag4C-2jp2A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 HIS A  92
TRP A  32
ASP A  96
HIS A  91
 None
 1.50A 5x1fN-2jp2A:
undetectable
5x1fP-2jp2A:
undetectable		 5x1fN-2jp2A:
13.64
5x1fP-2jp2A:
18.85