SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jpe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2jpe NUCLEAR INHIBITOR OF
PROTEIN PHOSPHATASE
1
(Mus
musculus) 		5 / 12 ILE A  86
ALA A  72
PHE A  14
LEU A  88
HIS A  77
 None
 1.05A 1fbyA-2jpeA:
undetectable		 1fbyA-2jpeA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2jpe NUCLEAR INHIBITOR OF
PROTEIN PHOSPHATASE
1
(Mus
musculus) 		5 / 12 ILE A  86
ALA A  72
PHE A  14
LEU A  88
HIS A  77
 None
 1.05A 1fbyB-2jpeA:
undetectable		 1fbyB-2jpeA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2jpe NUCLEAR INHIBITOR OF
PROTEIN PHOSPHATASE
1
(Mus
musculus) 		4 / 8 GLY A  52
GLY A 118
PHE A 117
SER A 120
 None
 0.76A 1jhqA-2jpeA:
undetectable		 1jhqA-2jpeA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 2jpe NUCLEAR INHIBITOR OF
PROTEIN PHOSPHATASE
1
(Mus
musculus) 		4 / 8 SER A 120
PHE A 117
TYR A 124
LEU A  88
 None
 1.05A 3jq7B-2jpeA:
undetectable		 3jq7B-2jpeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 2jpe NUCLEAR INHIBITOR OF
PROTEIN PHOSPHATASE
1
(Mus
musculus) 		5 / 12 LEU A  85
LEU A  29
ILE A  62
GLY A  52
HIS A  71
 None
 1.13A 3q95A-2jpeA:
undetectable		 3q95A-2jpeA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2jpe NUCLEAR INHIBITOR OF
PROTEIN PHOSPHATASE
1
(Mus
musculus) 		5 / 12 ILE A  86
ALA A  72
PHE A  14
LEU A  88
HIS A  77
 None
 1.14A 4nqaH-2jpeA:
undetectable		 4nqaH-2jpeA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JDC_D_6JPD302_1
(PTERIDINE REDUCTASE)		 2jpe NUCLEAR INHIBITOR OF
PROTEIN PHOSPHATASE
1
(Mus
musculus) 		5 / 11 SER A 120
PHE A 117
TYR A 124
VAL A  70
LEU A  88
 None
 1.46A 5jdcA-2jpeA:
undetectable
5jdcD-2jpeA:
undetectable		 5jdcA-2jpeA:
20.28
5jdcD-2jpeA:
20.28