SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jqd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Mus
musculus) 		4 / 6 ASN A  74
LEU A  80
LEU A  69
ILE A 100
 None
 1.01A 1z95A-2jqdA:
undetectable		 1z95A-2jqdA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Mus
musculus) 		5 / 12 LEU A  66
LEU A  90
ASN A  89
LEU A 109
LEU A  60
 None
 1.26A 1zucB-2jqdA:
undetectable		 1zucB-2jqdA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Mus
musculus) 		5 / 12 ILE A  57
PHE A  41
ASN A  74
ILE A   7
THR A  49
 None
 1.09A 2rlcA-2jqdA:
undetectable		 2rlcA-2jqdA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Mus
musculus) 		5 / 12 LEU A 109
ILE A 100
CYH A 123
LEU A  95
ASP A 119
 None
 1.07A 3ko0K-2jqdA:
undetectable
3ko0L-2jqdA:
undetectable
3ko0S-2jqdA:
undetectable
3ko0T-2jqdA:
undetectable		 3ko0K-2jqdA:
18.39
3ko0L-2jqdA:
18.39
3ko0S-2jqdA:
18.39
3ko0T-2jqdA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Mus
musculus) 		3 / 3 VAL A  52
SER A  29
LEU A  54
 None
 0.70A 3n8xA-2jqdA:
undetectable		 3n8xA-2jqdA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Mus
musculus) 		3 / 3 LEU A  24
MET A   3
ASP A  18
 None
 0.62A 4j7xB-2jqdA:
undetectable		 4j7xB-2jqdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Mus
musculus) 		4 / 8 LEU A  22
LEU A  47
LEU A  66
ILE A   7
 None
 0.84A 4klaA-2jqdA:
undetectable		 4klaA-2jqdA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Mus
musculus) 		4 / 7 ASN A  74
LEU A  80
LEU A  69
ILE A 100
 None
 0.98A 4okwA-2jqdA:
undetectable		 4okwA-2jqdA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Mus
musculus) 		5 / 11 ASN A  89
LEU A  90
LEU A  83
LEU A  69
LEU A  60
 None
 0.96A 4wg0B-2jqdA:
undetectable
4wg0C-2jqdA:
undetectable
4wg0D-2jqdA:
undetectable		 4wg0B-2jqdA:
6.37
4wg0C-2jqdA:
6.37
4wg0D-2jqdA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Mus
musculus) 		5 / 11 ASN A  89
LEU A  90
LEU A  83
LEU A  69
LEU A  60
 None
 0.95A 4wg0D-2jqdA:
undetectable
4wg0E-2jqdA:
undetectable
4wg0F-2jqdA:
undetectable		 4wg0D-2jqdA:
6.37
4wg0E-2jqdA:
6.37
4wg0F-2jqdA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Mus
musculus) 		5 / 11 LEU A  60
LEU A  69
ASN A  89
LEU A  90
LEU A  83
 None
 0.99A 4wg0C-2jqdA:
undetectable
4wg0D-2jqdA:
undetectable
4wg0E-2jqdA:
undetectable		 4wg0C-2jqdA:
6.37
4wg0D-2jqdA:
6.37
4wg0E-2jqdA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Mus
musculus) 		5 / 11 LEU A  60
LEU A  69
ASN A  89
LEU A  90
LEU A  83
 None
 0.98A 4wg0E-2jqdA:
undetectable
4wg0F-2jqdA:
undetectable
4wg0G-2jqdA:
undetectable		 4wg0E-2jqdA:
6.37
4wg0F-2jqdA:
6.37
4wg0G-2jqdA:
6.37