SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jre'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 2jre C60-1 PDZ DOMAIN
PEPTIDE
(-) 		4 / 4 LYS A  68
LEU A  70
LEU A  99
SER A  15
 None
 0.88A 1tt6A-2jreA:
undetectable		 1tt6A-2jreA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 2jre C60-1 PDZ DOMAIN
PEPTIDE
(-) 		4 / 5 LYS A  68
LEU A  70
LEU A  99
SER A  15
 None
 0.94A 1tt6B-2jreA:
undetectable		 1tt6B-2jreA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 2jre C60-1 PDZ DOMAIN
PEPTIDE
(-) 		4 / 6 LYS A  68
LEU A  70
LEU A  99
SER A  15
 None
 0.88A 1tz8C-2jreA:
undetectable
1tz8D-2jreA:
undetectable		 1tz8C-2jreA:
22.31
1tz8D-2jreA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2jre C60-1 PDZ DOMAIN
PEPTIDE
(-) 		5 / 12 LEU A  51
GLY A  54
ILE A  29
SER A  26
LEU A  27
 None
 1.16A 3gyqA-2jreA:
undetectable
3gyqB-2jreA:
undetectable		 3gyqA-2jreA:
18.91
3gyqB-2jreA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 2jre C60-1 PDZ DOMAIN
PEPTIDE
(-) 		4 / 7 LEU A  27
ILE A  46
ILE A  69
VAL A  48
 None
 0.86A 4ojbA-2jreA:
undetectable		 4ojbA-2jreA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2jre C60-1 PDZ DOMAIN
PEPTIDE
(-) 		4 / 6 LYS A  68
LEU A  70
LEU A  99
SER A  15
 None
 0.82A 4pwjA-2jreA:
undetectable		 4pwjA-2jreA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 2jre C60-1 PDZ DOMAIN
PEPTIDE
(-) 		4 / 7 LYS A  68
LEU A  70
LEU A  99
SER A  15
 None
 0.84A 4pwjB-2jreA:
undetectable		 4pwjB-2jreA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 2jre C60-1 PDZ DOMAIN
PEPTIDE
(-) 		4 / 6 LYS A  68
LEU A  70
LEU A  99
SER A  15
 None
 0.83A 5bojA-2jreA:
undetectable		 5bojA-2jreA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 2jre C60-1 PDZ DOMAIN
PEPTIDE
(-) 		4 / 7 LYS A  68
LEU A  70
LEU A  99
SER A  15
 None
 0.80A 5bojB-2jreA:
undetectable		 5bojB-2jreA:
22.31