SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YNN_C_RFPC1120_1 (DNA-DIRECTED RNA POLYMERASE BETA CHAIN)	2jsc	TRANSCRIPTIONAL REGULATOR RV1994C/MT2050 (Mycobacterium tuberculosis)	5 / 12	GLN A 39 ASP A 32 HIS A 43 LEU A 55 ILE A 26	None	1.21A	1ynnC-2jscA: undetectable	1ynnC-2jscA: 7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KMU_C_RFPC1401_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2jsc	TRANSCRIPTIONAL REGULATOR RV1994C/MT2050 (Mycobacterium tuberculosis)	5 / 12	GLN A 39 ASP A 32 HIS A 43 LEU A 55 ILE A 26	None	1.19A	4kmuC-2jscA: undetectable	4kmuC-2jscA: 7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KMU_H_RFPH1401_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2jsc	TRANSCRIPTIONAL REGULATOR RV1994C/MT2050 (Mycobacterium tuberculosis)	5 / 12	GLN A 39 ASP A 32 HIS A 43 LEU A 55 ILE A 26	None	1.05A	4kmuH-2jscA: 0.0	4kmuH-2jscA: 7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JQB_B_IBPB706_1 (ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1 ENVELOPE GLYCOPROTEIN 2)	2jsc	TRANSCRIPTIONAL REGULATOR RV1994C/MT2050 (Mycobacterium tuberculosis)	5 / 8	ALA A 19 LEU A 27 LEU A 86 LEU A 14 LEU A 63	None	1.33A	5jqbA-2jscA: undetectable 5jqbB-2jscA: undetectable	5jqbA-2jscA: 15.41 5jqbB-2jscA: 21.95

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1YNN_C_RFPC1120_1","DNA-DIRECTED RNA POLYMERASE BETA CHAIN","2jsc","TRANSCRIPTIONAL REGULATOR RV1994C\/MT2050","Mycobacterium tuberculosis",5,"GLN A  39;ASP A  32;HIS A  43;LEU A  55;ILE A  26","None","1.21A","1ynnC-2jscA:undetectable","1ynnC-2jscA:7.88"],["4KMU_C_RFPC1401_1","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","2jsc","TRANSCRIPTIONAL REGULATOR RV1994C\/MT2050","Mycobacterium tuberculosis",5,"GLN A  39;ASP A  32;HIS A  43;LEU A  55;ILE A  26","None","1.19A","4kmuC-2jscA:undetectable","4kmuC-2jscA:7.04"],["4KMU_H_RFPH1401_1","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","2jsc","TRANSCRIPTIONAL REGULATOR RV1994C\/MT2050","Mycobacterium tuberculosis",5,"GLN A  39;ASP A  32;HIS A  43;LEU A  55;ILE A  26","None","1.05A","4kmuH-2jscA:0.0","4kmuH-2jscA:7.04"],["5JQB_B_IBPB706_1","ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1;ENVELOPE GLYCOPROTEIN 2","2jsc","TRANSCRIPTIONAL REGULATOR RV1994C\/MT2050","Mycobacterium tuberculosis",5,"ALA A  19;LEU A  27;LEU A  86;LEU A  14;LEU A  63","None","1.33A","5jqbA-2jscA:undetectable;5jqbB-2jscA:undetectable","5jqbA-2jscA:15.41;5jqbB-2jscA:21.95"]]