SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jss'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
(Saccharomyces
cerevisiae) 		3 / 3 ILE A  69
ASP A  36
PHE A  33
 None
 0.44A 1uwjB-2jssA:
undetectable		 1uwjB-2jssA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
(Saccharomyces
cerevisiae) 		5 / 10 ILE A  62
ALA A  45
ALA A  42
ALA A  49
ILE A 131
 None
 1.17A 2aclC-2jssA:
undetectable		 2aclC-2jssA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 180
LEU A 178
VAL A 136
VAL A 144
 None
 0.98A 2bdmA-2jssA:
undetectable		 2bdmA-2jssA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 149
PRO A  18
LYS A  14
THR A  16
 None
 1.26A 2m2oB-2jssA:
undetectable		 2m2oB-2jssA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  70
PRO A  71
LEU A  74
 None
 0.46A 2qd5B-2jssA:
undetectable		 2qd5B-2jssA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  48
LEU A 115
ALA A  65
GLY A 126
THR A 134
 None
 1.00A 3c6gA-2jssA:
undetectable		 3c6gA-2jssA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
UNCHARACTERIZED
PROTEIN YER030W
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  86
SER A  90
LEU B  29
 None
 0.68A 3n8xA-2jssA:
undetectable		 3n8xA-2jssA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
UNCHARACTERIZED
PROTEIN YER030W
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 GLU B  56
LEU B  58
GLN A 166
GLY A 171
 None
 1.23A 3pp1A-2jssB:
undetectable		 3pp1A-2jssB:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
(Saccharomyces
cerevisiae) 		4 / 7 VAL A  12
PHE A 106
VAL A  34
ILE A  22
 None
 0.94A 3zjqA-2jssA:
undetectable		 3zjqA-2jssA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
(Saccharomyces
cerevisiae) 		4 / 7 VAL A  12
PHE A 106
VAL A  34
ILE A  22
 None
 0.95A 3zjqB-2jssA:
undetectable		 3zjqB-2jssA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
UNCHARACTERIZED
PROTEIN YER030W
(Saccharomyces
cerevisiae) 		4 / 6 ASP B  50
VAL A 157
SER A  26
ALA A 168
 None
 1.12A 4nedA-2jssB:
undetectable		 4nedA-2jssB:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
UNCHARACTERIZED
PROTEIN YER030W
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 11 ILE A  62
ASP B  28
ALA A 129
GLU A  61
VAL A 125
 None
 1.30A 5hw4B-2jssA:
undetectable		 5hw4B-2jssA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
UNCHARACTERIZED
PROTEIN YER030W
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP B  15
ASN B  20
PHE A 106
 None
 0.79A 5jglB-2jssB:
undetectable		 5jglB-2jssB:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 183
LEU A  30
LEU A 140
ASP A 176
GLU A 143
 None
 1.42A 5tixB-2jssA:
undetectable		 5tixB-2jssA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
(Saccharomyces
cerevisiae) 		3 / 3 PHE A  38
ASP A  36
LEU A 145
 None
 0.48A 5uhbC-2jssA:
1.7		 5uhbC-2jssA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
(Saccharomyces
cerevisiae) 		3 / 3 PHE A  38
ASP A  36
LEU A 145
 None
 0.40A 5uhcC-2jssA:
undetectable		 5uhcC-2jssA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_1
(-)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
UNCHARACTERIZED
PROTEIN YER030W
(Saccharomyces
cerevisiae) 		5 / 12 THR B  44
GLU A  73
LEU A 140
GLY B  41
HIS A  77
 None
 1.38A 6f3mA-2jssB:
undetectable		 6f3mA-2jssB:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_1
(-)		 2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
UNCHARACTERIZED
PROTEIN YER030W
(Saccharomyces
cerevisiae) 		5 / 12 THR B  44
GLU A  73
LEU A 140
GLY B  41
HIS A  77
 None
 1.37A 6f3mC-2jssB:
undetectable		 6f3mC-2jssB:
10.71