SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jsw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2jsw TALIN-1
(Mus
musculus) 		5 / 12 ILE A2345
ALA A2348
ALA A2349
ALA A2466
LEU A2326
 None
 1.02A 1fm6A-2jswA:
undetectable		 1fm6A-2jswA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 2jsw TALIN-1
(Mus
musculus) 		5 / 12 ILE A2345
ALA A2348
ALA A2349
ALA A2466
LEU A2326
 None
 1.01A 1xiuA-2jswA:
undetectable		 1xiuA-2jswA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2jsw TALIN-1
(Mus
musculus) 		5 / 12 LEU A2470
LEU A2424
ALA A2353
ALA A2411
VAL A2415
 None
 1.06A 3b0wA-2jswA:
undetectable		 3b0wA-2jswA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2jsw TALIN-1
(Mus
musculus) 		5 / 10 ALA A2353
LEU A2323
ILE A2345
LEU A2424
THR A2356
 None
 1.10A 3fl9E-2jswA:
undetectable		 3fl9E-2jswA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 2jsw TALIN-1
(Mus
musculus) 		5 / 9 ILE A2352
ALA A2473
LEU A2470
LEU A2323
ALA A2353
 None
 1.05A 3ozvB-2jswA:
2.5		 3ozvB-2jswA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 2jsw TALIN-1
(Mus
musculus) 		4 / 8 ALA A2363
LEU A2359
ALA A2396
ALA A2397
 None
 0.75A 3r9tA-2jswA:
undetectable		 3r9tA-2jswA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2jsw TALIN-1
(Mus
musculus) 		4 / 7 THR A2435
LEU A2438
THR A2356
LEU A2359
 None
 0.84A 4z90A-2jswA:
3.6
4z90B-2jswA:
3.6
4z90C-2jswA:
3.0
4z90D-2jswA:
3.0
4z90E-2jswA:
3.0		 4z90A-2jswA:
18.92
4z90B-2jswA:
18.92
4z90C-2jswA:
18.92
4z90D-2jswA:
18.92
4z90E-2jswA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2jsw TALIN-1
(Mus
musculus) 		4 / 8 THR A2356
LEU A2359
THR A2435
LEU A2438
 None
 0.79A 4z90F-2jswA:
2.7
4z90G-2jswA:
3.1
4z90H-2jswA:
3.1
4z90I-2jswA:
3.1
4z90J-2jswA:
3.1		 4z90F-2jswA:
18.92
4z90G-2jswA:
18.92
4z90H-2jswA:
18.92
4z90I-2jswA:
18.92
4z90J-2jswA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 2jsw TALIN-1
(Mus
musculus) 		4 / 5 GLU A2342
ALA A2330
GLU A2343
ASN A2340
 None
 1.16A 5dwkC-2jswA:
4.5		 5dwkC-2jswA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2jsw TALIN-1
(Mus
musculus) 		4 / 4 CYH A2442
LEU A2438
LEU A2393
ALA A2396
 None
 1.08A 5hpuA-2jswA:
undetectable
5hpuB-2jswA:
undetectable		 5hpuA-2jswA:
8.33
5hpuB-2jswA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 2jsw TALIN-1
(Mus
musculus) 		4 / 5 ALA A2466
ALA A2348
ILE A2352
LEU A2407
 None
 0.81A 5jncD-2jswA:
undetectable		 5jncD-2jswA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 2jsw TALIN-1
(Mus
musculus) 		4 / 4 ALA A2355
ALA A2358
ALA A2459
ALA A2462
 None
 0.81A 6gtqA-2jswA:
undetectable
6gtqB-2jswA:
undetectable		 6gtqA-2jswA:
23.76
6gtqB-2jswA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 2jsw TALIN-1
(Mus
musculus) 		4 / 4 ALA A2459
ALA A2462
ALA A2355
ALA A2358
 None
 0.81A 6gtqA-2jswA:
undetectable
6gtqB-2jswA:
undetectable		 6gtqA-2jswA:
23.76
6gtqB-2jswA:
23.76