SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jtc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		5 / 10 GLY A 243
GLN A 159
ASN A 161
TYR A 244
GLY A 190
 None
 1.42A 1kvlA-2jtcA:
undetectable		 1kvlA-2jtcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		4 / 8 ILE A  55
HIS A  59
LEU A 147
GLY A 250
 None
 0.87A 2vdbA-2jtcA:
undetectable		 2vdbA-2jtcA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		4 / 7 PRO A  26
PRO A 133
LEU A  73
PHE A  80
 None
 0.98A 2vl2B-2jtcA:
undetectable		 2vl2B-2jtcA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		4 / 8 LEU A   8
ILE A  55
HIS A  59
GLY A 250
 None
 0.98A 3b9lA-2jtcA:
undetectable		 3b9lA-2jtcA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		5 / 12 GLY A 136
THR A  52
SER A 126
SER A 141
ALA A 138
 None
 1.27A 3d91A-2jtcA:
undetectable		 3d91A-2jtcA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		5 / 9 VAL A   4
ASP A 175
ILE A 174
VAL A 184
GLN A 182
 None
 1.44A 3fhjD-2jtcA:
undetectable		 3fhjD-2jtcA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		5 / 9 VAL A   4
ASP A 175
ILE A 174
VAL A 184
GLN A 182
 None
 1.44A 3fhjF-2jtcA:
undetectable		 3fhjF-2jtcA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		4 / 8 VAL A 157
PHE A 151
THR A  52
VAL A 248
 None
 1.11A 3fhxB-2jtcA:
undetectable		 3fhxB-2jtcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		5 / 9 GLY A 201
VAL A   4
ASP A 175
ILE A 174
VAL A 184
 None
 1.46A 3fi0C-2jtcA:
undetectable		 3fi0C-2jtcA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		5 / 9 VAL A   4
ASP A 175
ILE A 174
VAL A 184
GLN A 182
 None
 1.40A 3fi0C-2jtcA:
undetectable		 3fi0C-2jtcA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		5 / 9 VAL A   4
ASP A 175
ILE A 174
VAL A 184
GLN A 182
 None
 1.43A 3fi0D-2jtcA:
undetectable		 3fi0D-2jtcA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		5 / 9 VAL A   4
ASP A 175
ILE A 174
VAL A 184
GLN A 182
 None
 1.43A 3fi0F-2jtcA:
undetectable		 3fi0F-2jtcA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		5 / 9 GLY A 201
VAL A   4
ASP A 175
ILE A 174
VAL A 184
 None
 1.46A 3fi0H-2jtcA:
undetectable		 3fi0H-2jtcA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		5 / 9 VAL A   4
ASP A 175
ILE A 174
VAL A 184
GLN A 182
 None
 1.40A 3fi0M-2jtcA:
undetectable		 3fi0M-2jtcA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		5 / 9 VAL A   4
ASP A 175
ILE A 174
VAL A 184
GLN A 182
 None
 1.40A 3fi0O-2jtcA:
undetectable		 3fi0O-2jtcA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		4 / 8 SER A  10
ASP A 200
ASP A 219
TYR A  21
 None
 1.13A 3havA-2jtcA:
undetectable		 3havA-2jtcA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		4 / 7 LEU A  86
GLY A 132
TYR A 131
SER A 135
 None
 0.99A 4cp3A-2jtcA:
undetectable
4cp3B-2jtcA:
undetectable		 4cp3A-2jtcA:
18.95
4cp3B-2jtcA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		5 / 12 SER A 135
TYR A 131
ALA A  88
ILE A 116
GLY A  46
 None
 1.21A 4iilA-2jtcA:
undetectable		 4iilA-2jtcA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		4 / 8 ASP A 175
LEU A 178
ASP A 200
ILE A 199
 None
 1.04A 4k0bA-2jtcA:
undetectable		 4k0bA-2jtcA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		4 / 8 ASP A 175
LEU A 178
ASP A 200
ILE A 199
 None
 1.06A 4l7iA-2jtcA:
undetectable		 4l7iA-2jtcA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		3 / 3 ASP A   9
HIS A 209
LYS A   5
 None
 0.74A 4qzuD-2jtcA:
undetectable		 4qzuD-2jtcA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2jtc STREPTOPAIN
(Streptococcus
pyogenes) 		5 / 12 PHE A 151
ILE A  90
GLY A 124
THR A  45
THR A 103
 None
 1.21A 5jlcA-2jtcA:
undetectable		 5jlcA-2jtcA:
19.88