SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN
(Escherichia
coli) 		4 / 8 TYR A 137
VAL A  37
GLY A 179
GLY A  35
 None
 0.79A 1ekjE-2jtyA:
undetectable
1ekjF-2jtyA:
undetectable		 1ekjE-2jtyA:
22.07
1ekjF-2jtyA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN
(Escherichia
coli) 		5 / 12 PHE A 177
VAL A  32
ILE A 131
ILE A  56
PHE A 154
 None
 1.26A 2ft9A-2jtyA:
undetectable		 2ft9A-2jtyA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN
(Escherichia
coli) 		4 / 6 PHE A 133
PHE A  73
GLY A 172
GLY A 173
 None
 0.93A 2qr2A-2jtyA:
undetectable
2qr2B-2jtyA:
undetectable		 2qr2A-2jtyA:
24.88
2qr2B-2jtyA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN
(Escherichia
coli) 		4 / 5 GLY A 172
GLY A 173
PHE A 133
PHE A  73
 None
 0.89A 2qr2A-2jtyA:
undetectable
2qr2B-2jtyA:
undetectable		 2qr2A-2jtyA:
24.88
2qr2B-2jtyA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN
(Escherichia
coli) 		5 / 6 PHE A 133
ILE A  56
PHE A  73
GLY A 172
GLY A 173
 None
 1.26A 2qx6A-2jtyA:
undetectable
2qx6B-2jtyA:
undetectable		 2qx6A-2jtyA:
24.88
2qx6B-2jtyA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN
(Escherichia
coli) 		5 / 12 THR A 130
ASN A  55
PHE A 133
PHE A  73
TYR A 158
 None
 1.48A 3rzeA-2jtyA:
undetectable		 3rzeA-2jtyA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN
(Escherichia
coli) 		5 / 12 GLY A 172
GLY A 173
PHE A 133
ILE A  56
PHE A  73
 None
 1.09A 4fglA-2jtyA:
undetectable
4fglB-2jtyA:
undetectable		 4fglA-2jtyA:
24.52
4fglB-2jtyA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN
(Escherichia
coli) 		5 / 11 GLY A 172
GLY A 173
PHE A 133
ILE A  56
PHE A  73
 None
 0.97A 4qoiA-2jtyA:
undetectable
4qoiB-2jtyA:
undetectable		 4qoiA-2jtyA:
24.76
4qoiB-2jtyA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN
(Escherichia
coli) 		5 / 9 ALA A  72
THR A 117
ALA A 116
ILE A 131
ALA A  70
 None
 1.05A 4qvqK-2jtyA:
undetectable
4qvqL-2jtyA:
undetectable		 4qvqK-2jtyA:
24.59
4qvqL-2jtyA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN
(Escherichia
coli) 		5 / 9 ALA A  72
THR A 117
ALA A 116
ILE A 131
ALA A  70
 None
 1.05A 4qvqY-2jtyA:
undetectable
4qvqZ-2jtyA:
undetectable		 4qvqY-2jtyA:
24.59
4qvqZ-2jtyA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN
(Escherichia
coli) 		5 / 12 GLU A 180
ALA A 150
VAL A 175
LEU A  86
GLY A 100
 None
 1.46A 5igpA-2jtyA:
undetectable		 5igpA-2jtyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN
(Escherichia
coli) 		5 / 10 GLY A 172
GLY A 173
PHE A 133
ILE A  56
PHE A  73
 None
 1.29A 5lbtA-2jtyA:
undetectable
5lbtB-2jtyA:
undetectable		 5lbtA-2jtyA:
20.66
5lbtB-2jtyA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN
(Escherichia
coli) 		5 / 12 LEU A  88
VAL A  99
ALA A  47
ALA A 139
GLY A 141
 None
 1.20A 5tzoB-2jtyA:
undetectable		 5tzoB-2jtyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN
(Escherichia
coli) 		4 / 7 ALA A 150
ILE A 103
GLN A 102
VAL A 101
 None
 0.91A 6cduF-2jtyA:
undetectable
6cduJ-2jtyA:
undetectable		 6cduF-2jtyA:
18.79
6cduJ-2jtyA:
18.79