SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jw4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AV2_B_DVAB8_0 (GRAMICIDIN A)	2jw4	CYTOPLASMIC PROTEIN NCK1 (Homo sapiens)	3 / 3	VAL A 9 VAL A 44 TRP A 33	None	0.68A	1av2A-2jw4A: undetectable 1av2B-2jw4A: undetectable	1av2A-2jw4A: 21.43 1av2B-2jw4A: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W5U_B_DVAB8_0 (GRAMICIDIN D)	2jw4	CYTOPLASMIC PROTEIN NCK1 (Homo sapiens)	3 / 3	VAL A 9 VAL A 11 TRP A 33	None	0.88A	1w5uA-2jw4A: undetectable 1w5uB-2jw4A: undetectable	1w5uA-2jw4A: 21.43 1w5uB-2jw4A: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W5U_B_DVAB8_0 (GRAMICIDIN D)	2jw4	CYTOPLASMIC PROTEIN NCK1 (Homo sapiens)	3 / 3	VAL A 9 VAL A 44 TRP A 33	None	0.80A	1w5uA-2jw4A: undetectable 1w5uB-2jw4A: undetectable	1w5uA-2jw4A: 21.43 1w5uB-2jw4A: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IZQ_C_DVAC8_0 (GRAMICIDIN D)	2jw4	CYTOPLASMIC PROTEIN NCK1 (Homo sapiens)	3 / 3	VAL A 11 TRP A 33 VAL A 9	None	0.87A	2izqC-2jw4A: undetectable 2izqD-2jw4A: undetectable	2izqC-2jw4A: 21.43 2izqD-2jw4A: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IZQ_C_DVAC8_0 (GRAMICIDIN D)	2jw4	CYTOPLASMIC PROTEIN NCK1 (Homo sapiens)	3 / 3	VAL A 44 TRP A 33 VAL A 9	None	0.72A	2izqC-2jw4A: undetectable 2izqD-2jw4A: undetectable	2izqC-2jw4A: 21.43 2izqD-2jw4A: 21.43

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AV2_B_DVAB8_0","GRAMICIDIN A","2jw4","CYTOPLASMIC PROTEIN NCK1","Homo sapiens",3,"VAL A   9;VAL A  44;TRP A  33","None","0.68A","1av2A-2jw4A:undetectable;1av2B-2jw4A:undetectable","1av2A-2jw4A:21.43;1av2B-2jw4A:21.43"],["1W5U_B_DVAB8_0","GRAMICIDIN D","2jw4","CYTOPLASMIC PROTEIN NCK1","Homo sapiens",3,"VAL A   9;VAL A  11;TRP A  33","None","0.88A","1w5uA-2jw4A:undetectable;1w5uB-2jw4A:undetectable","1w5uA-2jw4A:21.43;1w5uB-2jw4A:21.43"],["1W5U_B_DVAB8_0","GRAMICIDIN D","2jw4","CYTOPLASMIC PROTEIN NCK1","Homo sapiens",3,"VAL A   9;VAL A  44;TRP A  33","None","0.80A","1w5uA-2jw4A:undetectable;1w5uB-2jw4A:undetectable","1w5uA-2jw4A:21.43;1w5uB-2jw4A:21.43"],["2IZQ_C_DVAC8_0","GRAMICIDIN D","2jw4","CYTOPLASMIC PROTEIN NCK1","Homo sapiens",3,"VAL A  11;TRP A  33;VAL A   9","None","0.87A","2izqC-2jw4A:undetectable;2izqD-2jw4A:undetectable","2izqC-2jw4A:21.43;2izqD-2jw4A:21.43"],["2IZQ_C_DVAC8_0","GRAMICIDIN D","2jw4","CYTOPLASMIC PROTEIN NCK1","Homo sapiens",3,"VAL A  44;TRP A  33;VAL A   9","None","0.72A","2izqC-2jw4A:undetectable;2izqD-2jw4A:undetectable","2izqC-2jw4A:21.43;2izqD-2jw4A:21.43"]]