SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jw6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_A_ACTA3003_0 (BETA-CARBONIC ANHYDRASE)	2jw6	DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG (Homo sapiens)	4 / 8	CYH A 515 HIS A 536 CYH A 540 GLY A 541	ZN A 602 (-2.3A) ZN A 602 (-3.1A) ZN A 602 (-2.3A) None	0.84A	1ekjA-2jw6A: undetectable 1ekjB-2jw6A: undetectable	1ekjA-2jw6A: 12.67 1ekjB-2jw6A: 12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_G_ACTG3002_0 (BETA-CARBONIC ANHYDRASE)	2jw6	DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG (Homo sapiens)	4 / 8	CYH A 515 HIS A 536 CYH A 540 GLY A 541	ZN A 602 (-2.3A) ZN A 602 (-3.1A) ZN A 602 (-2.3A) None	0.91A	1ekjG-2jw6A: undetectable 1ekjH-2jw6A: undetectable	1ekjG-2jw6A: 12.67 1ekjH-2jw6A: 12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ICX_F_SC2F1_1 (CETUXIMAB FAB LIGHT CHAIN MEDITOPE)	2jw6	DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG (Homo sapiens)	3 / 3	VAL A 521 GLN A 537 CYH A 540	None None ZN A 602 (-2.3A)	0.73A	5icxC-2jw6A: undetectable 5icxF-2jw6A: undetectable	5icxC-2jw6A: 11.36 5icxF-2jw6A: 13.46

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EKJ_A_ACTA3003_0","BETA-CARBONIC ANHYDRASE","2jw6","DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG","Homo sapiens",4,"CYH A 515;HIS A 536;CYH A 540;GLY A 541"," ZN A 602 (-2.3A); ZN A 602 (-3.1A); ZN A 602 (-2.3A);None","0.84A","1ekjA-2jw6A:undetectable;1ekjB-2jw6A:undetectable","1ekjA-2jw6A:12.67;1ekjB-2jw6A:12.67"],["1EKJ_G_ACTG3002_0","BETA-CARBONIC ANHYDRASE","2jw6","DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG","Homo sapiens",4,"CYH A 515;HIS A 536;CYH A 540;GLY A 541"," ZN A 602 (-2.3A); ZN A 602 (-3.1A); ZN A 602 (-2.3A);None","0.91A","1ekjG-2jw6A:undetectable;1ekjH-2jw6A:undetectable","1ekjG-2jw6A:12.67;1ekjH-2jw6A:12.67"],["5ICX_F_SC2F1_1","CETUXIMAB FAB LIGHT CHAIN;MEDITOPE","2jw6","DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG","Homo sapiens",3,"VAL A 521;GLN A 537;CYH A 540","None;None; ZN A 602 (-2.3A)","0.73A","5icxC-2jw6A:undetectable;5icxF-2jw6A:undetectable","5icxC-2jw6A:11.36;5icxF-2jw6A:13.46"]]