SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 ALA A 382
VAL A 396
TRP A 401
 CA  A 471 ( 4.3A)
None
None
 0.71A 1kqeA-2jxyA:
undetectable
1kqeE-2jxyA:
undetectable		 1kqeA-2jxyA:
4.42
1kqeE-2jxyA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 ALA A 382
VAL A 396
TRP A 401
 CA  A 471 ( 4.3A)
None
None
 0.71A 1kqeB-2jxyA:
undetectable
1kqeD-2jxyA:
undetectable		 1kqeB-2jxyA:
4.42
1kqeD-2jxyA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 TRP A 401
ALA A 382
VAL A 396
 None
CA  A 471 ( 4.3A)
None
 0.72A 1kqeB-2jxyA:
undetectable
1kqeD-2jxyA:
undetectable		 1kqeB-2jxyA:
4.42
1kqeD-2jxyA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 TRP A 401
ALA A 382
VAL A 396
 None
CA  A 471 ( 4.3A)
None
 0.73A 1kqeA-2jxyA:
undetectable
1kqeE-2jxyA:
undetectable		 1kqeA-2jxyA:
4.42
1kqeE-2jxyA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 ALA A 382
VAL A 396
TRP A 401
 CA  A 471 ( 4.3A)
None
None
 0.77A 1micA-2jxyA:
undetectable
1micB-2jxyA:
undetectable		 1micA-2jxyA:
5.15
1micB-2jxyA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 8 SER A 464
PHE A 300
ASN A 465
TRP A 307
 None
 1.12A 1p6kA-2jxyA:
undetectable		 1p6kA-2jxyA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 8 SER A 464
PHE A 300
ASN A 465
TRP A 307
 None
 1.07A 1p6kB-2jxyA:
undetectable		 1p6kB-2jxyA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 8 SER A 464
PHE A 300
ASN A 465
TRP A 307
 None
 1.20A 1rs6A-2jxyA:
undetectable		 1rs6A-2jxyA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 8 SER A 464
PHE A 300
ASN A 465
TRP A 307
 None
 1.17A 1rs6B-2jxyA:
undetectable		 1rs6B-2jxyA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 8 SER A 464
PHE A 300
ASN A 465
TRP A 307
 None
 1.06A 1rs7B-2jxyA:
undetectable		 1rs7B-2jxyA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 8 SER A 464
PHE A 300
ASN A 465
TRP A 307
 None
 1.12A 1zzqA-2jxyA:
undetectable		 1zzqA-2jxyA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 8 SER A 464
PHE A 300
ASN A 465
TRP A 307
 None
 1.09A 1zzqB-2jxyA:
undetectable		 1zzqB-2jxyA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 8 SER A 464
PHE A 300
ASN A 465
TRP A 307
 None
 1.10A 1zzuA-2jxyA:
undetectable		 1zzuA-2jxyA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 8 SER A 464
PHE A 300
ASN A 465
TRP A 307
 None
 1.09A 1zzuB-2jxyA:
undetectable		 1zzuB-2jxyA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 8 SER A 464
PHE A 300
ASN A 465
TRP A 307
 None
 1.09A 3n62B-2jxyA:
undetectable		 3n62B-2jxyA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		5 / 10 PHE A 453
TYR A 400
ASP A 411
ASP A 404
TYR A 390
 None
 1.33A 4qb9C-2jxyA:
undetectable		 4qb9C-2jxyA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 7 ASN A 465
PHE A 468
TRP A 307
PHE A 300
 None
 1.40A 4v32A-2jxyA:
0.3		 4v32A-2jxyA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		 2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 7 ASN A 465
PHE A 468
TRP A 307
PHE A 300
 None
 1.36A 4v32B-2jxyA:
undetectable		 4v32B-2jxyA:
17.53