SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2jyb DIHYDROFOLATE
REDUCTASE
(Haloferax
volcanii) 		5 / 12 ALA A  97
LEU A 113
ILE A 105
ILE A 100
THR A  96
 None
 1.09A 1re7A-2jybA:
18.0		 1re7A-2jybA:
36.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 2jyb DIHYDROFOLATE
REDUCTASE
(Haloferax
volcanii) 		4 / 7 ALA A   7
GLY A 102
ILE A 105
PRO A 132
 None
 0.73A 2fxdB-2jybA:
undetectable		 2fxdB-2jybA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2jyb DIHYDROFOLATE
REDUCTASE
(Haloferax
volcanii) 		5 / 12 ALA A  97
LEU A 113
ILE A 105
ILE A 100
THR A  96
 None
 1.02A 4ptjA-2jybA:
18.1		 4ptjA-2jybA:
35.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 2jyb DIHYDROFOLATE
REDUCTASE
(Haloferax
volcanii) 		4 / 8 ILE A 100
GLN A 110
VAL A 117
ASP A  29
 None
 0.90A 5vlmF-2jybA:
undetectable		 5vlmF-2jybA:
23.41