SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jyz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2jyz CG7054-PA
(Drosophila
melanogaster) 		5 / 12 LEU A 118
LEU A 153
ILE A  84
GLY A  86
SER A  53
 None
 1.00A 1cqeA-2jyzA:
undetectable		 1cqeA-2jyzA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2jyz CG7054-PA
(Drosophila
melanogaster) 		5 / 12 LEU A 118
LEU A 153
ILE A  84
GLY A  86
SER A  53
 None
 1.00A 1cqeB-2jyzA:
undetectable		 1cqeB-2jyzA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 2jyz CG7054-PA
(Drosophila
melanogaster) 		5 / 10 GLN A 121
HIS A  95
VAL A  82
LEU A 153
THR A 128
 None
 1.34A 1rj6A-2jyzA:
undetectable		 1rj6A-2jyzA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2jyz CG7054-PA
(Drosophila
melanogaster) 		4 / 7 ASP A  64
ALA A  65
ASP A  62
TYR A 166
 None
 1.20A 3rodD-2jyzA:
undetectable		 3rodD-2jyzA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2jyz CG7054-PA
(Drosophila
melanogaster) 		4 / 7 ILE A 131
THR A 128
VAL A 101
PHE A 147
 None
 1.20A 4iarA-2jyzA:
undetectable		 4iarA-2jyzA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2jyz CG7054-PA
(Drosophila
melanogaster) 		5 / 12 GLY A 138
ILE A 177
ARG A 139
ASN A 174
PHE A 142
 None
 1.11A 5fa8A-2jyzA:
undetectable		 5fa8A-2jyzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2jyz CG7054-PA
(Drosophila
melanogaster) 		4 / 7 LEU A  59
THR A  57
ILE A 125
LEU A  55
 None
 0.98A 5fxtA-2jyzA:
undetectable		 5fxtA-2jyzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2jyz CG7054-PA
(Drosophila
melanogaster) 		3 / 3 TYR A  73
TYR A 166
SER A 103
 None
 0.81A 5iktB-2jyzA:
undetectable		 5iktB-2jyzA:
17.04