SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 2jzd REPLICASE
POLYPROTEIN 1AB
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 ILE A 593
LEU A 627
GLY A 609
ALA A 620
LEU A 648
 None
 1.05A 1r9oA-2jzdA:
undetectable		 1r9oA-2jzdA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 2jzd REPLICASE
POLYPROTEIN 1AB
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 8 ASP A 552
SER A 585
TYR A 583
HIS A 613
 None
 1.23A 2bteD-2jzdA:
undetectable		 2bteD-2jzdA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2jzd REPLICASE
POLYPROTEIN 1AB
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 ARG A 625
VAL A 635
THR A 528
 None
 0.84A 2nnkA-2jzdA:
undetectable		 2nnkA-2jzdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 2jzd REPLICASE
POLYPROTEIN 1AB
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 8 ASP A 552
SER A 585
TYR A 583
HIS A 613
 None
 1.02A 2v0gA-2jzdA:
undetectable		 2v0gA-2jzdA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2jzd REPLICASE
POLYPROTEIN 1AB
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 ARG A 625
VAL A 635
THR A 528
 None
 0.81A 3nduD-2jzdA:
undetectable		 3nduD-2jzdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2jzd REPLICASE
POLYPROTEIN 1AB
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 ARG A 625
VAL A 635
THR A 528
 None
 0.86A 3pwrA-2jzdA:
undetectable		 3pwrA-2jzdA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2jzd REPLICASE
POLYPROTEIN 1AB
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 ARG A 625
VAL A 635
THR A 528
 None
 0.86A 3tl9A-2jzdA:
undetectable		 3tl9A-2jzdA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 2jzd REPLICASE
POLYPROTEIN 1AB
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 THR A 528
ASN A 616
PHE A 615
 None
 0.83A 4pd9A-2jzdA:
undetectable		 4pd9A-2jzdA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2jzd REPLICASE
POLYPROTEIN 1AB
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 VAL A 529
ARG A 579
PRO A 602
 None
 0.82A 5koxA-2jzdA:
undetectable		 5koxA-2jzdA:
15.42