SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k1g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 2k1g LIPOPROTEIN SPR
(Escherichia
coli) 		4 / 5 SER A  61
ARG A  86
HIS A 131
HIS A 119
 None
 1.21A 1s19A-2k1gA:
0.0		 1s19A-2k1gA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 2k1g LIPOPROTEIN SPR
(Escherichia
coli) 		4 / 8 TYR A  56
ASP A  67
SER A  69
HIS A 119
 None
 1.23A 2bteA-2k1gA:
undetectable		 2bteA-2k1gA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2k1g LIPOPROTEIN SPR
(Escherichia
coli) 		5 / 12 SER A  69
PHE A  76
ARG A 157
THR A  88
GLN A  91
 None
 1.49A 2fj1A-2k1gA:
undetectable		 2fj1A-2k1gA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2k1g LIPOPROTEIN SPR
(Escherichia
coli) 		4 / 8 ARG A 104
LEU A  82
GLY A  81
PHE A  80
 None
 0.91A 2tsrB-2k1gA:
undetectable		 2tsrB-2k1gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2k1g LIPOPROTEIN SPR
(Escherichia
coli) 		4 / 7 SER A  69
VAL A 120
VAL A  72
LEU A  84
 None
 0.58A 3o14A-2k1gA:
undetectable		 3o14A-2k1gA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2k1g LIPOPROTEIN SPR
(Escherichia
coli) 		5 / 12 SER A  61
ARG A  86
VAL A 130
HIS A 131
HIS A 119
 None
 1.40A 3vt7A-2k1gA:
undetectable		 3vt7A-2k1gA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2k1g LIPOPROTEIN SPR
(Escherichia
coli) 		4 / 8 TYR A  56
PHE A  71
VAL A  72
HIS A 119
 None
 0.86A 4eyzA-2k1gA:
8.6		 4eyzA-2k1gA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2k1g LIPOPROTEIN SPR
(Escherichia
coli) 		4 / 8 TYR A  56
PHE A  71
VAL A  72
HIS A 119
 None
 0.86A 4eyzB-2k1gA:
8.6		 4eyzB-2k1gA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 2k1g LIPOPROTEIN SPR
(Escherichia
coli) 		5 / 12 SER A  61
ARG A  86
VAL A 130
HIS A 131
HIS A 119
 None
 1.42A 4rujA-2k1gA:
undetectable		 4rujA-2k1gA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 2k1g LIPOPROTEIN SPR
(Escherichia
coli) 		5 / 12 SER A  61
ARG A  86
VAL A 130
HIS A 131
HIS A 119
 None
 1.42A 5h1eA-2k1gA:
0.0		 5h1eA-2k1gA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2k1g LIPOPROTEIN SPR
(Escherichia
coli) 		4 / 8 SER A  61
ARG A  86
GLN A  47
TRP A  51
 None
 1.33A 5vunA-2k1gA:
undetectable		 5vunA-2k1gA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 2k1g LIPOPROTEIN SPR
(Escherichia
coli) 		4 / 5 ILE A 122
GLN A  79
THR A  75
THR A 105
 None
 0.91A 6f3mD-2k1gA:
undetectable		 6f3mD-2k1gA:
13.33