SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2k1s INNER MEMBRANE
LIPOPROTEIN YIAD
(Escherichia
coli) 		4 / 5 SER A  93
SER A  96
PHE A  38
VAL A  70
 None
 1.48A 1oipA-2k1sA:
undetectable		 1oipA-2k1sA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2k1s INNER MEMBRANE
LIPOPROTEIN YIAD
(Escherichia
coli) 		5 / 12 ALA A  43
PHE A  38
ILE A 136
THR A 110
VAL A 134
 None
 0.92A 3rukB-2k1sA:
undetectable		 3rukB-2k1sA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2k1s INNER MEMBRANE
LIPOPROTEIN YIAD
(Escherichia
coli) 		5 / 12 GLY A  79
GLY A  78
LEU A 113
GLY A  72
ASP A  75
 None
 0.94A 4fp9A-2k1sA:
undetectable		 4fp9A-2k1sA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2k1s INNER MEMBRANE
LIPOPROTEIN YIAD
(Escherichia
coli) 		5 / 12 GLY A  79
GLY A  78
LEU A 113
GLY A  72
ASP A  75
 None
 0.94A 4fp9C-2k1sA:
undetectable		 4fp9C-2k1sA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2k1s INNER MEMBRANE
LIPOPROTEIN YIAD
(Escherichia
coli) 		5 / 12 GLY A  79
GLY A  78
LEU A 113
GLY A  72
ASP A  75
 None
 0.94A 4fp9F-2k1sA:
undetectable		 4fp9F-2k1sA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2k1s INNER MEMBRANE
LIPOPROTEIN YIAD
(Escherichia
coli) 		5 / 12 ALA A  43
PHE A  38
ILE A 136
THR A 110
VAL A 134
 None
 0.93A 4nkxB-2k1sA:
undetectable		 4nkxB-2k1sA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2k1s INNER MEMBRANE
LIPOPROTEIN YIAD
(Escherichia
coli) 		3 / 3 PHE A  38
ASP A  39
LYS A  46
 None
 0.82A 6awtD-2k1sA:
undetectable		 6awtD-2k1sA:
18.86