SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DRA_B_MTXB361_1 (DIHYDROFOLATE REDUCTASE)	2k22	PUTATIVE UNCHARACTERIZED PROTEIN TA0895 (Thermoplasma acidophilum)	6 / 12	ILE A 58 LEU A 71 ILE A 75 ILE A 81 TYR A 6 THR A 43	None	1.49A	1draB-2k22A: undetectable	1draB-2k22A: 16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ONI_A_BEZA502_0 (14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN)	2k22	PUTATIVE UNCHARACTERIZED PROTEIN TA0895 (Thermoplasma acidophilum)	4 / 6	PHE A 21 ASN A 22 ILE A 24 GLY A 23	None	1.07A	1oniA-2k22A: undetectable 1oniB-2k22A: undetectable	1oniA-2k22A: 19.01 1oniB-2k22A: 19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNH_B_9CRB501_1 (CYTOCHROME P450 2C8)	2k22	PUTATIVE UNCHARACTERIZED PROTEIN TA0895 (Thermoplasma acidophilum)	5 / 9	ILE A 24 THR A 73 VAL A 2 ILE A 81 VAL A 60	None	1.36A	2nnhB-2k22A: undetectable	2nnhB-2k22A: 11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PYY_B_STIB4_2 (V-ABL ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1 ISOFORM B VARIANT)	2k22	PUTATIVE UNCHARACTERIZED PROTEIN TA0895 (Thermoplasma acidophilum)	4 / 5	VAL A 4 ILE A 58 MET A 68 ARG A 33	None	1.44A	3pyyB-2k22A: undetectable	3pyyB-2k22A: 12.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DRA_B_MTXB361_1","DIHYDROFOLATE REDUCTASE","2k22","PUTATIVE UNCHARACTERIZED PROTEIN TA0895","Thermoplasma acidophilum",6,"ILE A  58;LEU A  71;ILE A  75;ILE A  81;TYR A   6;THR A  43","None","1.49A","1draB-2k22A:undetectable","1draB-2k22A:16.88"],["1ONI_A_BEZA502_0","14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN","2k22","PUTATIVE UNCHARACTERIZED PROTEIN TA0895","Thermoplasma acidophilum",4,"PHE A  21;ASN A  22;ILE A  24;GLY A  23","None","1.07A","1oniA-2k22A:undetectable;1oniB-2k22A:undetectable","1oniA-2k22A:19.01;1oniB-2k22A:19.01"],["2NNH_B_9CRB501_1","CYTOCHROME P450 2C8","2k22","PUTATIVE UNCHARACTERIZED PROTEIN TA0895","Thermoplasma acidophilum",5,"ILE A  24;THR A  73;VAL A   2;ILE A  81;VAL A  60","None","1.36A","2nnhB-2k22A:undetectable","2nnhB-2k22A:11.37"],["3PYY_B_STIB4_2","V-ABL ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1 ISOFORM B VARIANT","2k22","PUTATIVE UNCHARACTERIZED PROTEIN TA0895","Thermoplasma acidophilum",4,"VAL A   4;ILE A  58;MET A  68;ARG A  33","None","1.44A","3pyyB-2k22A:undetectable","3pyyB-2k22A:12.75"]]