SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 2k2c RING FINGER AND CHY
ZINC FINGER
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LYS A  30
LEU A  37
GLU A  59
ALA A  31
 None
None
None
ZN  A 138 (-4.0A)
 1.17A 1eta1-2k2cA:
undetectable		 1eta1-2k2cA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 2k2c RING FINGER AND CHY
ZINC FINGER
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LYS A  30
LEU A  37
GLU A  59
ALA A  31
 None
None
None
ZN  A 138 (-4.0A)
 1.13A 1eta2-2k2cA:
undetectable		 1eta2-2k2cA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 2k2c RING FINGER AND CHY
ZINC FINGER
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LYS A  30
LEU A  37
GLU A  59
ALA A  31
 None
None
None
ZN  A 138 (-4.0A)
 1.15A 1etb1-2k2cA:
undetectable		 1etb1-2k2cA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2k2c RING FINGER AND CHY
ZINC FINGER
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A  54
ASP A  45
ASP A  49
 None
 0.89A 2ejtA-2k2cA:
undetectable		 2ejtA-2k2cA:
16.36