SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A29_A_TFPA153_1
(CALMODULIN)		 2k2i CENTRIN-2
(Homo
sapiens) 		5 / 8 ILE A 121
LEU A 126
MET A 145
ALA A 149
VAL A 157
 None
 0.72A 1a29A-2k2iA:
10.8		 1a29A-2k2iA:
35.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A29_A_TFPA153_1
(CALMODULIN)		 2k2i CENTRIN-2
(Homo
sapiens) 		5 / 8 LEU A 126
MET A 145
GLU A 148
ALA A 149
VAL A 157
 None
 1.19A 1a29A-2k2iA:
10.8		 1a29A-2k2iA:
35.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 2k2i CENTRIN-2
(Homo
sapiens) 		5 / 9 ILE A 121
LEU A 126
MET A 145
ALA A 149
VAL A 157
 None
 0.89A 1ctrA-2k2iA:
10.1		 1ctrA-2k2iA:
35.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 2k2i CENTRIN-2
(Homo
sapiens) 		5 / 9 LEU A 126
MET A 145
GLU A 148
ALA A 149
VAL A 157
 None
 1.27A 1ctrA-2k2iA:
10.1		 1ctrA-2k2iA:
35.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2k2i CENTRIN-2
(Homo
sapiens) 		6 / 12 PHE A 113
ILE A 121
LEU A 126
GLU A 148
VAL A 157
MET A 166
 None
 0.97A 1lxfC-2k2iA:
8.7		 1lxfC-2k2iA:
44.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2k2i CENTRIN-2
(Homo
sapiens) 		6 / 12 PHE A 113
ILE A 121
LEU A 126
ILE A 146
GLU A 148
VAL A 157
 None
 0.90A 1lxfC-2k2iA:
8.7		 1lxfC-2k2iA:
44.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 2k2i CENTRIN-2
(Homo
sapiens) 		4 / 8 ILE A 165
ILE A 146
LEU A 126
ILE A 121
 None
 0.84A 4dtaB-2k2iA:
undetectable		 4dtaB-2k2iA:
14.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 2k2i CENTRIN-2
(Homo
sapiens) 		5 / 8 ILE A 121
LEU A 126
MET A 145
ALA A 149
VAL A 157
 None
 0.68A 4rjdA-2k2iA:
10.6		 4rjdA-2k2iA:
51.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 2k2i CENTRIN-2
(Homo
sapiens) 		4 / 7 LEU A 126
MET A 145
ALA A 149
MET A 166
 None
 0.85A 4rjdB-2k2iA:
10.5		 4rjdB-2k2iA:
51.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 2k2i CENTRIN-2
(Homo
sapiens) 		4 / 7 PHE A 113
LEU A 126
ALA A 149
MET A 166
 None
 0.72A 4rjdB-2k2iA:
10.5		 4rjdB-2k2iA:
51.39