SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 2k2o MYOFERLIN
(Homo
sapiens) 		3 / 3 GLU A 994
TRP A1008
LYS A 918
 None
 1.29A 1qu2A-2k2oA:
undetectable		 1qu2A-2k2oA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 2k2o MYOFERLIN
(Homo
sapiens) 		3 / 3 GLU A 976
HIS A 927
GLU A 929
 None
 0.75A 2x45B-2k2oA:
undetectable		 2x45B-2k2oA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 2k2o MYOFERLIN
(Homo
sapiens) 		3 / 3 GLU A 976
HIS A 927
GLU A 929
 None
 0.81A 2x45C-2k2oA:
undetectable		 2x45C-2k2oA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2k2o MYOFERLIN
(Homo
sapiens) 		5 / 12 ALA A 956
ASN A 957
ILE A 984
ASP A 983
ARG A1022
 None
 1.45A 3w37A-2k2oA:
undetectable		 3w37A-2k2oA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2k2o MYOFERLIN
(Homo
sapiens) 		5 / 12 ALA A 956
ASN A 957
ILE A 984
ASP A 983
ARG A1022
 None
 1.44A 3welA-2k2oA:
undetectable		 3welA-2k2oA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 2k2o MYOFERLIN
(Homo
sapiens) 		3 / 3 TRP A 980
TRP A 975
THR A 968
 None
 1.28A 4bboB-2k2oA:
undetectable		 4bboB-2k2oA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2k2o MYOFERLIN
(Homo
sapiens) 		3 / 3 LYS A 991
TYR A 982
ARG A1021
 None
 1.28A 4gc9A-2k2oA:
undetectable		 4gc9A-2k2oA:
17.28