SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k31'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2k31 PHOSPHODIESTERASE
5A, CGMP-SPECIFIC
(Mus
musculus) 		4 / 8 TYR A 251
SER A 176
GLN A 273
ILE A 256
 None
35G  A   1 (-2.7A)
None
None
 1.16A 2xz5B-2k31A:
undetectable
2xz5E-2k31A:
undetectable		 2xz5B-2k31A:
23.81
2xz5E-2k31A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2k31 PHOSPHODIESTERASE
5A, CGMP-SPECIFIC
(Mus
musculus) 		5 / 11 SER A 192
VAL A 180
LEU A 190
ALA A 224
VAL A 268
 None
 1.25A 4e0fA-2k31A:
undetectable		 4e0fA-2k31A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2k31 PHOSPHODIESTERASE
5A, CGMP-SPECIFIC
(Mus
musculus) 		4 / 7 VAL A 269
ILE A 261
LEU A 203
LEU A 194
 None
 0.96A 4xo7A-2k31A:
undetectable		 4xo7A-2k31A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EU8_B_010B6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 2k31 PHOSPHODIESTERASE
5A, CGMP-SPECIFIC
(Mus
musculus) 		4 / 5 ASN A 276
LEU A 257
THR A 253
CYH A 258
 None
 1.45A 5eu8A-2k31A:
0.0		 5eu8A-2k31A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 2k31 PHOSPHODIESTERASE
5A, CGMP-SPECIFIC
(Mus
musculus) 		3 / 3 CYH A 159
LYS A 161
HIS A 160
 None
 1.11A 5js5A-2k31A:
undetectable		 5js5A-2k31A:
20.33