SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2k3n TUSP1
(Nephila
antipodiana) 		5 / 11 SER A 127
ILE A  56
ALA A  60
SER A  63
LEU A  64
 None
 1.07A 1eqgB-2k3nA:
undetectable		 1eqgB-2k3nA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2k3n TUSP1
(Nephila
antipodiana) 		4 / 7 ILE A  66
LEU A  64
LEU A 126
VAL A  80
 None
 1.00A 3r9vA-2k3nA:
undetectable
3r9vB-2k3nA:
undetectable		 3r9vA-2k3nA:
19.93
3r9vB-2k3nA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2k3n TUSP1
(Nephila
antipodiana) 		5 / 9 ALA A  99
GLY A 101
LEU A 126
LEU A  72
LEU A 104
 None
 1.16A 3wdmC-2k3nA:
undetectable		 3wdmC-2k3nA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2k3n TUSP1
(Nephila
antipodiana) 		5 / 9 ALA A 115
SER A 116
ALA A 112
ALA A  14
ALA A  21
 None
 1.26A 4twdA-2k3nA:
undetectable
4twdB-2k3nA:
undetectable
4twdC-2k3nA:
undetectable
4twdD-2k3nA:
undetectable
4twdE-2k3nA:
undetectable		 4twdA-2k3nA:
17.67
4twdB-2k3nA:
17.67
4twdC-2k3nA:
17.67
4twdD-2k3nA:
17.67
4twdE-2k3nA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2k3n TUSP1
(Nephila
antipodiana) 		5 / 8 ALA A  14
ALA A  21
ALA A 115
SER A 116
ALA A 112
 None
 1.23A 4twdF-2k3nA:
undetectable
4twdG-2k3nA:
undetectable
4twdH-2k3nA:
undetectable
4twdI-2k3nA:
undetectable
4twdJ-2k3nA:
undetectable		 4twdF-2k3nA:
17.67
4twdG-2k3nA:
17.67
4twdH-2k3nA:
17.67
4twdI-2k3nA:
17.67
4twdJ-2k3nA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2k3n TUSP1
(Nephila
antipodiana) 		5 / 12 ASP A  69
GLY A  57
ASN A  55
LEU A  52
ALA A  39
 None
 1.43A 5kbwA-2k3nA:
2.6		 5kbwA-2k3nA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2k3n TUSP1
(Nephila
antipodiana) 		5 / 12 SER A 127
ALA A  39
ALA A  60
SER A  63
LEU A  64
 None
 0.84A 5kirB-2k3nA:
undetectable		 5kirB-2k3nA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2k3n TUSP1
(Nephila
antipodiana) 		5 / 9 SER A  51
ALA A  46
SER A  45
SER A  47
GLY A  81
 None
 1.19A 6bklA-2k3nA:
undetectable
6bklB-2k3nA:
undetectable
6bklC-2k3nA:
undetectable
6bklD-2k3nA:
undetectable		 6bklA-2k3nA:
12.80
6bklB-2k3nA:
12.80
6bklC-2k3nA:
12.80
6bklD-2k3nA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 2k3n TUSP1
(Nephila
antipodiana) 		5 / 9 ALA A  46
SER A  45
SER A  47
GLY A  81
SER A  51
 None
 1.22A 6bklE-2k3nA:
undetectable
6bklF-2k3nA:
undetectable
6bklG-2k3nA:
undetectable
6bklH-2k3nA:
undetectable		 6bklE-2k3nA:
12.80
6bklF-2k3nA:
12.80
6bklG-2k3nA:
12.80
6bklH-2k3nA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2k3n TUSP1
(Nephila
antipodiana) 		4 / 6 SER A  20
ALA A  25
ALA A 115
SER A 116
 None
 0.92A 6bocA-2k3nA:
undetectable
6bocB-2k3nA:
undetectable
6bocC-2k3nA:
undetectable
6bocD-2k3nA:
undetectable		 6bocA-2k3nA:
12.80
6bocB-2k3nA:
12.80
6bocC-2k3nA:
12.80
6bocD-2k3nA:
12.80