SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 2k3x CHROMATIN
MODIFICATION-RELATED
PROTEIN EAF3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  97
ILE A  27
PHE A   8
ALA A   9
GLU A 103
 None
 1.16A 2j0dA-2k3xA:
undetectable		 2j0dA-2k3xA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2k3x CHROMATIN
MODIFICATION-RELATED
PROTEIN EAF3
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  21
TRP A  84
GLY A  83
 None
 0.77A 3l35A-2k3xA:
undetectable
3l35H-2k3xA:
undetectable		 3l35A-2k3xA:
16.96
3l35H-2k3xA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2k3x CHROMATIN
MODIFICATION-RELATED
PROTEIN EAF3
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  21
TRP A  84
GLY A  83
 None
 0.79A 3l35B-2k3xA:
undetectable
3l35K-2k3xA:
undetectable		 3l35B-2k3xA:
16.96
3l35K-2k3xA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 2k3x CHROMATIN
MODIFICATION-RELATED
PROTEIN EAF3
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  56
GLN A  51
THR A  53
LEU A  10
 None
 1.15A 6f3mD-2k3xA:
undetectable		 6f3mD-2k3xA:
15.56