SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k4h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IJD_A_C2FA314_0 (UNCHARACTERIZED PROTEIN)	2k4h	HIV-2 MYRISTOYLATED MATRIX PROTEIN (Human immunodeficiency virus 2)	5 / 12	LEU A 75 LEU A 21 ILE A 85 LEU A 64 ILE A 60	None None MYR A 1 ( 3.4A) None None	1.12A	3ijdA-2k4hA: undetectable	3ijdA-2k4hA: 17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IJD_B_C2FB314_0 (UNCHARACTERIZED PROTEIN)	2k4h	HIV-2 MYRISTOYLATED MATRIX PROTEIN (Human immunodeficiency virus 2)	5 / 12	LEU A 75 LEU A 21 ILE A 85 LEU A 64 ILE A 60	None None MYR A 1 ( 3.4A) None None	1.11A	3ijdB-2k4hA: undetectable	3ijdB-2k4hA: 17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VRM_A_VD3A502_1 (VITAMIN D(3) 25-HYDROXYLASE)	2k4h	HIV-2 MYRISTOYLATED MATRIX PROTEIN (Human immunodeficiency virus 2)	5 / 12	ILE A 85 LEU A 31 LEU A 51 ALA A 37 ILE A 19	MYR A 1 ( 3.4A) None MYR A 1 (-3.3A) None None	1.07A	3vrmA-2k4hA: undetectable	3vrmA-2k4hA: 14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_B_PCFB1806_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	2k4h	HIV-2 MYRISTOYLATED MATRIX PROTEIN (Human immunodeficiency virus 2)	4 / 6	ILE A 19 ILE A 60 LEU A 51 PHE A 44	None None MYR A 1 (-3.3A) None	0.88A	5vkqB-2k4hA: undetectable 5vkqC-2k4hA: undetectable	5vkqB-2k4hA: 6.68 5vkqC-2k4hA: 6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_C_PCFC1807_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	2k4h	HIV-2 MYRISTOYLATED MATRIX PROTEIN (Human immunodeficiency virus 2)	4 / 6	ILE A 19 ILE A 60 LEU A 51 PHE A 44	None None MYR A 1 (-3.3A) None	0.90A	5vkqC-2k4hA: undetectable 5vkqD-2k4hA: undetectable	5vkqC-2k4hA: 6.68 5vkqD-2k4hA: 6.68

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3IJD_A_C2FA314_0","UNCHARACTERIZED PROTEIN","2k4h","HIV-2 MYRISTOYLATED MATRIX PROTEIN","Human immunodeficiency virus 2",5,"LEU A  75;LEU A  21;ILE A  85;LEU A  64;ILE A  60","None;None;MYR A   1 ( 3.4A);None;None","1.12A","3ijdA-2k4hA:undetectable","3ijdA-2k4hA:17.80"],["3IJD_B_C2FB314_0","UNCHARACTERIZED PROTEIN","2k4h","HIV-2 MYRISTOYLATED MATRIX PROTEIN","Human immunodeficiency virus 2",5,"LEU A  75;LEU A  21;ILE A  85;LEU A  64;ILE A  60","None;None;MYR A   1 ( 3.4A);None;None","1.11A","3ijdB-2k4hA:undetectable","3ijdB-2k4hA:17.80"],["3VRM_A_VD3A502_1","VITAMIN D(3) 25-HYDROXYLASE","2k4h","HIV-2 MYRISTOYLATED MATRIX PROTEIN","Human immunodeficiency virus 2",5,"ILE A  85;LEU A  31;LEU A  51;ALA A  37;ILE A  19","MYR A   1 ( 3.4A);None;MYR A   1 (-3.3A);None;None","1.07A","3vrmA-2k4hA:undetectable","3vrmA-2k4hA:14.63"],["5VKQ_B_PCFB1806_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","2k4h","HIV-2 MYRISTOYLATED MATRIX PROTEIN","Human immunodeficiency virus 2",4,"ILE A  19;ILE A  60;LEU A  51;PHE A  44","None;None;MYR A   1 (-3.3A);None","0.88A","5vkqB-2k4hA:undetectable;5vkqC-2k4hA:undetectable","5vkqB-2k4hA:6.68;5vkqC-2k4hA:6.68"],["5VKQ_C_PCFC1807_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","2k4h","HIV-2 MYRISTOYLATED MATRIX PROTEIN","Human immunodeficiency virus 2",4,"ILE A  19;ILE A  60;LEU A  51;PHE A  44","None;None;MYR A   1 (-3.3A);None","0.90A","5vkqC-2k4hA:undetectable;5vkqD-2k4hA:undetectable","5vkqC-2k4hA:6.68;5vkqD-2k4hA:6.68"]]