SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RTS_B_D16B409_1 (THYMIDYLATE SYNTHASE)	2k4j	PUTATIVE TRANSCRIPTIONAL REGULATOR (Helicobacter pylori)	4 / 7	ILE A 23 LEU A 113 GLY A 58 TYR A 111	None	0.75A	1rtsB-2k4jA: undetectable	1rtsB-2k4jA: 16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TSR_B_D16B409_1 (THYMIDYLATE SYNTHASE)	2k4j	PUTATIVE TRANSCRIPTIONAL REGULATOR (Helicobacter pylori)	4 / 8	ILE A 23 LEU A 113 GLY A 58 TYR A 111	None	0.88A	2tsrB-2k4jA: undetectable	2tsrB-2k4jA: 16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IQQ_A_D16A402_1 (THYMIDYLATE SYNTHASE)	2k4j	PUTATIVE TRANSCRIPTIONAL REGULATOR (Helicobacter pylori)	4 / 7	ILE A 23 LEU A 113 GLY A 58 TYR A 111	None	0.86A	4iqqA-2k4jA: undetectable	4iqqA-2k4jA: 14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IQQ_D_D16D402_1 (THYMIDYLATE SYNTHASE)	2k4j	PUTATIVE TRANSCRIPTIONAL REGULATOR (Helicobacter pylori)	4 / 8	ILE A 23 LEU A 113 GLY A 58 TYR A 111	None	0.87A	4iqqD-2k4jA: undetectable	4iqqD-2k4jA: 14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NOO_A_D16A402_1 (THYMIDYLATE SYNTHASE)	2k4j	PUTATIVE TRANSCRIPTIONAL REGULATOR (Helicobacter pylori)	4 / 7	ILE A 23 LEU A 113 GLY A 58 TYR A 111	None	0.86A	5nooA-2k4jA: undetectable	5nooA-2k4jA: 14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NOO_D_D16D402_1 (THYMIDYLATE SYNTHASE)	2k4j	PUTATIVE TRANSCRIPTIONAL REGULATOR (Helicobacter pylori)	4 / 8	ILE A 23 LEU A 113 GLY A 58 TYR A 111	None	0.86A	5nooD-2k4jA: undetectable	5nooD-2k4jA: 14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V0V_A_8QSA615_1 (SERUM ALBUMIN)	2k4j	PUTATIVE TRANSCRIPTIONAL REGULATOR (Helicobacter pylori)	4 / 8	LEU A 53 TYR A 111 LEU A 40 ILE A 85	None	0.94A	5v0vA-2k4jA: undetectable	5v0vA-2k4jA: 10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X5Q_E_D16E402_1 (THYMIDYLATE SYNTHASE)	2k4j	PUTATIVE TRANSCRIPTIONAL REGULATOR (Helicobacter pylori)	4 / 6	ILE A 23 LEU A 113 GLY A 58 TYR A 111	None	0.85A	5x5qE-2k4jA: undetectable	5x5qE-2k4jA: 14.88

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RTS_B_D16B409_1","THYMIDYLATE SYNTHASE","2k4j","PUTATIVE TRANSCRIPTIONAL REGULATOR","Helicobacter pylori",4,"ILE A  23;LEU A 113;GLY A  58;TYR A 111","None","0.75A","1rtsB-2k4jA:undetectable","1rtsB-2k4jA:16.40"],["2TSR_B_D16B409_1","THYMIDYLATE SYNTHASE","2k4j","PUTATIVE TRANSCRIPTIONAL REGULATOR","Helicobacter pylori",4,"ILE A  23;LEU A 113;GLY A  58;TYR A 111","None","0.88A","2tsrB-2k4jA:undetectable","2tsrB-2k4jA:16.40"],["4IQQ_A_D16A402_1","THYMIDYLATE SYNTHASE","2k4j","PUTATIVE TRANSCRIPTIONAL REGULATOR","Helicobacter pylori",4,"ILE A  23;LEU A 113;GLY A  58;TYR A 111","None","0.86A","4iqqA-2k4jA:undetectable","4iqqA-2k4jA:14.01"],["4IQQ_D_D16D402_1","THYMIDYLATE SYNTHASE","2k4j","PUTATIVE TRANSCRIPTIONAL REGULATOR","Helicobacter pylori",4,"ILE A  23;LEU A 113;GLY A  58;TYR A 111","None","0.87A","4iqqD-2k4jA:undetectable","4iqqD-2k4jA:14.01"],["5NOO_A_D16A402_1","THYMIDYLATE SYNTHASE","2k4j","PUTATIVE TRANSCRIPTIONAL REGULATOR","Helicobacter pylori",4,"ILE A  23;LEU A 113;GLY A  58;TYR A 111","None","0.86A","5nooA-2k4jA:undetectable","5nooA-2k4jA:14.01"],["5NOO_D_D16D402_1","THYMIDYLATE SYNTHASE","2k4j","PUTATIVE TRANSCRIPTIONAL REGULATOR","Helicobacter pylori",4,"ILE A  23;LEU A 113;GLY A  58;TYR A 111","None","0.86A","5nooD-2k4jA:undetectable","5nooD-2k4jA:14.01"],["5V0V_A_8QSA615_1","SERUM ALBUMIN","2k4j","PUTATIVE TRANSCRIPTIONAL REGULATOR","Helicobacter pylori",4,"LEU A  53;TYR A 111;LEU A  40;ILE A  85","None","0.94A","5v0vA-2k4jA:undetectable","5v0vA-2k4jA:10.03"],["5X5Q_E_D16E402_1","THYMIDYLATE SYNTHASE","2k4j","PUTATIVE TRANSCRIPTIONAL REGULATOR","Helicobacter pylori",4,"ILE A  23;LEU A 113;GLY A  58;TYR A 111","None","0.85A","5x5qE-2k4jA:undetectable","5x5qE-2k4jA:14.88"]]