SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_A_CELA682_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2k4k	GENERAL STRESS PROTEIN 13 (Bacillus subtilis)	5 / 12	ALA A 78 VAL A 35 GLY A 22 ALA A 23 LEU A 18	None	0.96A	3ln1A-2k4kA: undetectable	3ln1A-2k4kA: 13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_B_CELB682_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2k4k	GENERAL STRESS PROTEIN 13 (Bacillus subtilis)	5 / 12	ALA A 78 VAL A 35 GLY A 22 ALA A 23 LEU A 18	None	0.95A	3ln1B-2k4kA: undetectable	3ln1B-2k4kA: 13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_C_CELC682_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2k4k	GENERAL STRESS PROTEIN 13 (Bacillus subtilis)	5 / 12	ALA A 78 VAL A 35 GLY A 22 ALA A 23 LEU A 18	None	0.96A	3ln1C-2k4kA: undetectable	3ln1C-2k4kA: 13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_D_CELD682_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2k4k	GENERAL STRESS PROTEIN 13 (Bacillus subtilis)	5 / 12	ALA A 78 VAL A 35 GLY A 22 ALA A 23 LEU A 18	None	0.95A	3ln1D-2k4kA: undetectable	3ln1D-2k4kA: 13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JW1_A_CELA602_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2k4k	GENERAL STRESS PROTEIN 13 (Bacillus subtilis)	5 / 12	ALA A 78 VAL A 35 GLY A 22 ALA A 23 LEU A 18	None	0.94A	5jw1A-2k4kA: undetectable	5jw1A-2k4kA: 13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JW1_B_CELB602_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2k4k	GENERAL STRESS PROTEIN 13 (Bacillus subtilis)	5 / 12	ALA A 78 VAL A 35 GLY A 22 ALA A 23 LEU A 18	None	0.93A	5jw1B-2k4kA: undetectable	5jw1B-2k4kA: 13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KIR_A_RCXA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2k4k	GENERAL STRESS PROTEIN 13 (Bacillus subtilis)	5 / 12	ALA A 78 VAL A 35 GLY A 22 ALA A 23 LEU A 18	None	0.89A	5kirA-2k4kA: undetectable	5kirA-2k4kA: 14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KIR_B_RCXB601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2k4k	GENERAL STRESS PROTEIN 13 (Bacillus subtilis)	5 / 12	ALA A 78 VAL A 35 GLY A 22 ALA A 23 LEU A 18	None	0.92A	5kirB-2k4kA: undetectable	5kirB-2k4kA: 14.40

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3LN1_A_CELA682_1","PROSTAGLANDIN G\/H SYNTHASE 2","2k4k","GENERAL STRESS PROTEIN 13","Bacillus subtilis",5,"ALA A  78;VAL A  35;GLY A  22;ALA A  23;LEU A  18","None","0.96A","3ln1A-2k4kA:undetectable","3ln1A-2k4kA:13.55"],["3LN1_B_CELB682_1","PROSTAGLANDIN G\/H SYNTHASE 2","2k4k","GENERAL STRESS PROTEIN 13","Bacillus subtilis",5,"ALA A  78;VAL A  35;GLY A  22;ALA A  23;LEU A  18","None","0.95A","3ln1B-2k4kA:undetectable","3ln1B-2k4kA:13.55"],["3LN1_C_CELC682_1","PROSTAGLANDIN G\/H SYNTHASE 2","2k4k","GENERAL STRESS PROTEIN 13","Bacillus subtilis",5,"ALA A  78;VAL A  35;GLY A  22;ALA A  23;LEU A  18","None","0.96A","3ln1C-2k4kA:undetectable","3ln1C-2k4kA:13.55"],["3LN1_D_CELD682_1","PROSTAGLANDIN G\/H SYNTHASE 2","2k4k","GENERAL STRESS PROTEIN 13","Bacillus subtilis",5,"ALA A  78;VAL A  35;GLY A  22;ALA A  23;LEU A  18","None","0.95A","3ln1D-2k4kA:undetectable","3ln1D-2k4kA:13.55"],["5JW1_A_CELA602_1","PROSTAGLANDIN G\/H SYNTHASE 2","2k4k","GENERAL STRESS PROTEIN 13","Bacillus subtilis",5,"ALA A  78;VAL A  35;GLY A  22;ALA A  23;LEU A  18","None","0.94A","5jw1A-2k4kA:undetectable","5jw1A-2k4kA:13.98"],["5JW1_B_CELB602_1","PROSTAGLANDIN G\/H SYNTHASE 2","2k4k","GENERAL STRESS PROTEIN 13","Bacillus subtilis",5,"ALA A  78;VAL A  35;GLY A  22;ALA A  23;LEU A  18","None","0.93A","5jw1B-2k4kA:undetectable","5jw1B-2k4kA:13.98"],["5KIR_A_RCXA601_1","PROSTAGLANDIN G\/H SYNTHASE 2","2k4k","GENERAL STRESS PROTEIN 13","Bacillus subtilis",5,"ALA A  78;VAL A  35;GLY A  22;ALA A  23;LEU A  18","None","0.89A","5kirA-2k4kA:undetectable","5kirA-2k4kA:14.40"],["5KIR_B_RCXB601_1","PROSTAGLANDIN G\/H SYNTHASE 2","2k4k","GENERAL STRESS PROTEIN 13","Bacillus subtilis",5,"ALA A  78;VAL A  35;GLY A  22;ALA A  23;LEU A  18","None","0.92A","5kirB-2k4kA:undetectable","5kirB-2k4kA:14.40"]]