SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 LEU A  92
SER A  33
VAL A  60
LEU A  62
ALA A  26
 None
 1.28A 1fo4A-2k4mA:
undetectable		 1fo4A-2k4mA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 LEU A  92
GLY A  43
ILE A  96
VAL A  39
ILE A  93
 None
 0.91A 1sdtA-2k4mA:
undetectable		 1sdtA-2k4mA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 LEU A  92
GLY A  43
ILE A  96
VAL A  39
 None
 0.71A 2aojB-2k4mA:
undetectable		 2aojB-2k4mA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A  61
ILE A  74
VAL A  50
 None
 0.70A 2avvD-2k4mA:
undetectable		 2avvD-2k4mA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 LEU A  92
GLY A  43
ILE A  96
VAL A  39
ILE A  93
 None
 0.93A 2o4pB-2k4mA:
undetectable		 2o4pB-2k4mA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 LEU A  92
GLY A  43
ILE A  96
VAL A  39
ILE A  93
 None
 0.98A 3d1yB-2k4mA:
undetectable		 3d1yB-2k4mA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 VAL A  50
ASN A  23
TYR A  94
ILE A  30
 None
 0.92A 3q5sA-2k4mA:
undetectable		 3q5sA-2k4mA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  92
GLY A  43
ILE A  96
VAL A  39
ILE A  93
 None
 0.92A 3tkgB-2k4mA:
undetectable		 3tkgB-2k4mA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 LEU A  92
SER A  33
VAL A  60
LEU A  62
ALA A  26
 None
 1.30A 3unaA-2k4mA:
undetectable		 3unaA-2k4mA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 LEU A  92
SER A  33
VAL A  60
LEU A  62
ALA A  26
 None
 1.29A 3unaB-2k4mA:
undetectable		 3unaB-2k4mA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 LEU A  92
SER A  33
VAL A  60
LEU A  62
ALA A  26
 None
 1.29A 3uncA-2k4mA:
undetectable		 3uncA-2k4mA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 LEU A  92
SER A  33
VAL A  60
LEU A  62
ALA A  26
 None
 1.30A 3uncB-2k4mA:
undetectable		 3uncB-2k4mA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A  45
ILE A  67
ASP A  78
ILE A  79
ARG A  97
 None
 1.00A 4iv0B-2k4mA:
8.9		 4iv0B-2k4mA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  92
GLY A  43
ILE A  96
VAL A  39
ILE A  93
 None
 0.97A 5kqyA-2k4mA:
undetectable		 5kqyA-2k4mA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 2k4m UPF0146 PROTEIN
MTH_1000
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 LEU A  92
GLY A  43
ILE A  96
VAL A  39
ILE A  93
 None
 0.93A 5kr2D-2k4mA:
undetectable		 5kr2D-2k4mA:
16.99