SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		4 / 8 LEU A 117
GLU A  26
GLU A 119
ILE A  24
 None
 0.76A 1qvtA-2k4wA:
undetectable		 1qvtA-2k4wA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 10 LEU A  94
GLU A  44
MET A   7
GLU A 107
ALA A 111
 None
 1.34A 1wrkA-2k4wA:
undetectable
1wrkB-2k4wA:
undetectable		 1wrkA-2k4wA:
24.43
1wrkB-2k4wA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		4 / 7 GLY A  71
HIS A  73
ASP A  75
PRO A 140
 None
ZN  A 156 ( 3.2A)
None
None
 1.16A 2armA-2k4wA:
undetectable		 2armA-2k4wA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		3 / 3 ASP A  93
ILE A 127
VAL A 109
 ZN  A 156 (-1.6A)
None
None
 0.68A 2avvD-2k4wA:
undetectable		 2avvD-2k4wA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		4 / 4 HIS A  48
HIS A  50
HIS A  73
HIS A 128
 CU1  A 155 (-3.1A)
CU1  A 155 (-3.3A)
ZN  A 156 ( 3.2A)
CU1  A 155 (-3.0A)
 0.72A 2wkoA-2k4wA:
14.9		 2wkoA-2k4wA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		4 / 5 HIS A  48
HIS A  50
HIS A  73
HIS A 128
 CU1  A 155 (-3.1A)
CU1  A 155 (-3.3A)
ZN  A 156 ( 3.2A)
CU1  A 155 (-3.0A)
 0.69A 2wkoF-2k4wA:
14.7		 2wkoF-2k4wA:
31.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 12 ALA A 149
THR A  11
GLY A  14
LEU A  97
ASN A   8
 None
 1.00A 2y7hB-2k4wA:
undetectable		 2y7hB-2k4wA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 12 ALA A 149
THR A  11
GLY A  14
LEU A  97
ASN A   8
 None
 0.99A 2y7hC-2k4wA:
undetectable		 2y7hC-2k4wA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 10 GLY A  72
ALA A  51
HIS A  73
HIS A  48
HIS A 128
 None
None
ZN  A 156 ( 3.2A)
CU1  A 155 (-3.1A)
CU1  A 155 (-3.0A)
 1.46A 3boyA-2k4wA:
0.0
3boyC-2k4wA:
0.0		 3boyA-2k4wA:
18.24
3boyC-2k4wA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 10 HIS A  48
HIS A 128
GLY A  72
ALA A  51
HIS A  73
 CU1  A 155 (-3.1A)
CU1  A 155 (-3.0A)
None
None
ZN  A 156 ( 3.2A)
 1.47A 3boyA-2k4wA:
0.0
3boyB-2k4wA:
0.0		 3boyA-2k4wA:
18.24
3boyB-2k4wA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 10 HIS A  48
HIS A 128
GLY A  72
ALA A  51
HIS A  73
 CU1  A 155 (-3.1A)
CU1  A 155 (-3.0A)
None
None
ZN  A 156 ( 3.2A)
 1.47A 3boyB-2k4wA:
0.0
3boyC-2k4wA:
0.0		 3boyB-2k4wA:
18.24
3boyC-2k4wA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 12 ALA A 149
ALA A  66
GLY A  71
VAL A   5
MET A   7
 None
 1.08A 3c6gA-2k4wA:
undetectable		 3c6gA-2k4wA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		3 / 3 HIS A 128
HIS A  50
MET A 126
 CU1  A 155 (-3.0A)
CU1  A 155 (-3.3A)
CU1  A 155 ( 4.2A)
 1.01A 3mihA-2k4wA:
undetectable		 3mihA-2k4wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 12 HIS A  50
GLY A  72
HIS A  48
HIS A  82
GLY A 145
 CU1  A 155 (-3.3A)
None
CU1  A 155 (-3.1A)
ZN  A 156 (-3.3A)
None
 1.17A 4bz6C-2k4wA:
undetectable		 4bz6C-2k4wA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 12 LEU A  94
LEU A 114
HIS A  90
LEU A  74
ILE A  49
 None
None
ZN  A 156 (-3.2A)
None
None
 0.99A 4x1fA-2k4wA:
undetectable		 4x1fA-2k4wA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 12 LEU A  94
LEU A 114
HIS A  90
LEU A  74
ILE A  49
 None
None
ZN  A 156 (-3.2A)
None
None
 1.03A 4x1gA-2k4wA:
undetectable		 4x1gA-2k4wA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 12 PRO A 140
HIS A  50
GLY A  72
HIS A  48
LEU A 141
 None
CU1  A 155 (-3.3A)
None
CU1  A 155 (-3.1A)
None
 1.35A 5eeiA-2k4wA:
undetectable		 5eeiA-2k4wA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 12 PRO A 140
HIS A  50
GLY A  72
HIS A  48
LEU A 141
 None
CU1  A 155 (-3.3A)
None
CU1  A 155 (-3.1A)
None
 1.34A 5eeiB-2k4wA:
undetectable		 5eeiB-2k4wA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		3 / 3 HIS A  73
ASP A  93
HIS A  82
 ZN  A 156 ( 3.2A)
ZN  A 156 (-1.6A)
ZN  A 156 (-3.3A)
 0.90A 5n1tW-2k4wA:
1.9		 5n1tW-2k4wA:
21.86