SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AJ6_A_NOVA1_1 (GYRASE)	2k4y	FEOA-LIKE PROTEIN (Clostridium acetobutylicum)	5 / 9	ASN A 8 GLU A 69 ILE A 54 PRO A 53 ALA A 48	None	1.44A	1aj6A-2k4yA: undetectable	1aj6A-2k4yA: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XRZ_B_ACTB1463_0 (DEOXYRIBODIPYRIMIDIN E PHOTOLYASE)	2k4y	FEOA-LIKE PROTEIN (Clostridium acetobutylicum)	4 / 7	VAL A 18 ILE A 36 GLY A 39 THR A 40	None	0.80A	2xrzB-2k4yA: undetectable	2xrzB-2k4yA: 11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4H1N_A_CGEA505_1 (CYTOCHROME P450 2B4)	2k4y	FEOA-LIKE PROTEIN (Clostridium acetobutylicum)	5 / 11	ILE A 44 ILE A 36 LEU A 63 VAL A 16 VAL A 18	None	1.06A	4h1nA-2k4yA: undetectable	4h1nA-2k4yA: 11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4URO_C_NOVC2000_1 (DNA GYRASE SUBUNIT B)	2k4y	FEOA-LIKE PROTEIN (Clostridium acetobutylicum)	5 / 12	ASN A 8 GLU A 69 ILE A 54 PRO A 53 ALA A 48	None	1.34A	4uroC-2k4yA: undetectable	4uroC-2k4yA: 16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XUM_A_IMNA502_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2k4y	FEOA-LIKE PROTEIN (Clostridium acetobutylicum)	5 / 7	GLU A 9 ILE A 73 ARG A 66 LEU A 63 ILE A 54	None	1.21A	4xumA-2k4yA: undetectable	4xumA-2k4yA: 15.27

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AJ6_A_NOVA1_1","GYRASE","2k4y","FEOA-LIKE PROTEIN","Clostridium acetobutylicum",5,"ASN A   8;GLU A  69;ILE A  54;PRO A  53;ALA A  48","None","1.44A","1aj6A-2k4yA:undetectable","1aj6A-2k4yA:19.56"],["2XRZ_B_ACTB1463_0","DEOXYRIBODIPYRIMIDINE PHOTOLYASE","2k4y","FEOA-LIKE PROTEIN","Clostridium acetobutylicum",4,"VAL A  18;ILE A  36;GLY A  39;THR A  40","None","0.80A","2xrzB-2k4yA:undetectable","2xrzB-2k4yA:11.69"],["4H1N_A_CGEA505_1","CYTOCHROME P450 2B4","2k4y","FEOA-LIKE PROTEIN","Clostridium acetobutylicum",5,"ILE A  44;ILE A  36;LEU A  63;VAL A  16;VAL A  18","None","1.06A","4h1nA-2k4yA:undetectable","4h1nA-2k4yA:11.06"],["4URO_C_NOVC2000_1","DNA GYRASE SUBUNIT B","2k4y","FEOA-LIKE PROTEIN","Clostridium acetobutylicum",5,"ASN A   8;GLU A  69;ILE A  54;PRO A  53;ALA A  48","None","1.34A","4uroC-2k4yA:undetectable","4uroC-2k4yA:16.88"],["4XUM_A_IMNA502_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","2k4y","FEOA-LIKE PROTEIN","Clostridium acetobutylicum",5,"GLU A   9;ILE A  73;ARG A  66;LEU A  63;ILE A  54","None","1.21A","4xumA-2k4yA:undetectable","4xumA-2k4yA:15.27"]]