SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2k6b PROGRAMMED CELL
DEATH PROTEIN 5
(Homo
sapiens) 		4 / 7 ILE A  75
GLN A  82
LEU A  83
LEU A  48
 None
 0.97A 2qqcB-2k6bA:
undetectable
2qqcC-2k6bA:
undetectable		 2qqcB-2k6bA:
20.63
2qqcC-2k6bA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2k6b PROGRAMMED CELL
DEATH PROTEIN 5
(Homo
sapiens) 		4 / 7 LEU A  83
LEU A  48
ILE A  75
GLN A  82
 None
 0.98A 2qqcA-2k6bA:
undetectable
2qqcF-2k6bA:
undetectable		 2qqcA-2k6bA:
17.82
2qqcF-2k6bA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2k6b PROGRAMMED CELL
DEATH PROTEIN 5
(Homo
sapiens) 		4 / 7 LEU A  83
LEU A  48
ILE A  75
GLN A  82
 None
 1.02A 2qqcG-2k6bA:
undetectable
2qqcJ-2k6bA:
undetectable		 2qqcG-2k6bA:
17.82
2qqcJ-2k6bA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2k6b PROGRAMMED CELL
DEATH PROTEIN 5
(Homo
sapiens) 		4 / 7 LEU A  83
LEU A  48
ILE A  75
GLN A  82
 None
 0.99A 2qqcI-2k6bA:
undetectable
2qqcL-2k6bA:
undetectable		 2qqcI-2k6bA:
17.82
2qqcL-2k6bA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2k6b PROGRAMMED CELL
DEATH PROTEIN 5
(Homo
sapiens) 		3 / 3 LEU A  74
TYR A  73
GLN A  76
 None
 0.57A 2wekA-2k6bA:
undetectable		 2wekA-2k6bA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2k6b PROGRAMMED CELL
DEATH PROTEIN 5
(Homo
sapiens) 		3 / 3 ARG A  40
LYS A  33
GLU A  36
 None
 0.78A 5d0yA-2k6bA:
undetectable		 5d0yA-2k6bA:
22.40