SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 2k6g REPLICATION FACTOR C
SUBUNIT 1
(Homo
sapiens) 		5 / 9 ILE A 470
LEU A 407
THR A 438
LEU A 465
GLY A 409
 None
 1.42A 3nxuB-2k6gA:
undetectable		 3nxuB-2k6gA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2k6g REPLICATION FACTOR C
SUBUNIT 1
(Homo
sapiens) 		4 / 6 ARG A 423
LYS A 427
ILE A 430
LEU A 475
 None
 0.96A 4em2A-2k6gA:
undetectable		 4em2A-2k6gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 2k6g REPLICATION FACTOR C
SUBUNIT 1
(Homo
sapiens) 		3 / 3 ARG A 452
ARG A 423
ARG A 388
 None
 0.90A 5vcgA-2k6gA:
undetectable		 5vcgA-2k6gA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2k6g REPLICATION FACTOR C
SUBUNIT 1
(Homo
sapiens) 		5 / 12 GLU A 431
ILE A 430
LEU A 410
GLY A 409
THR A 467
 None
 1.18A 5x5qB-2k6gA:
undetectable		 5x5qB-2k6gA:
20.49