SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 2k77 NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 10 LEU A  14
VAL A  13
ILE A  34
GLU A  94
VAL A 103
 None
 0.93A 1cqpA-2k77A:
undetectable
1cqpB-2k77A:
undetectable		 1cqpA-2k77A:
17.30
1cqpB-2k77A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 2k77 NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 LEU A 124
ASN A 125
LEU A 127
GLY A 128
LEU A 131
 None
 1.11A 1gs4A-2k77A:
undetectable		 1gs4A-2k77A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2k77 NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 GLY A 143
ARG A 135
GLU A  94
HIS A 100
LEU A  98
 None
 1.15A 1mj2A-2k77A:
undetectable
1mj2B-2k77A:
undetectable		 1mj2A-2k77A:
19.12
1mj2B-2k77A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 2k77 NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 GLY A 143
ARG A 135
GLU A  94
HIS A 100
LEU A  98
 None
 1.13A 1mj2C-2k77A:
undetectable
1mj2D-2k77A:
undetectable		 1mj2C-2k77A:
19.12
1mj2D-2k77A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2k77 NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		4 / 8 GLY A  37
VAL A  13
GLU A  41
ILE A  34
 None
 0.90A 1pk7B-2k77A:
undetectable		 1pk7B-2k77A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 2k77 NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 LEU A 124
ASN A 125
LEU A 127
GLY A 128
LEU A 131
 None
 0.97A 2oz7A-2k77A:
undetectable		 2oz7A-2k77A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2k77 NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 ILE A  60
LEU A  53
ALA A  52
ILE A 113
LEU A 109
 None
 1.06A 3dauA-2k77A:
undetectable		 3dauA-2k77A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2k77 NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 ILE A  60
LEU A  53
ALA A  52
ILE A 113
LEU A 109
 None
 0.99A 4psyA-2k77A:
undetectable		 4psyA-2k77A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		 2k77 NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 LEU A 112
ALA A  47
GLN A  51
SER A  57
LEU A  36
 None
 1.27A 4udaA-2k77A:
undetectable		 4udaA-2k77A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2k77 NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 LEU A  14
ILE A 108
GLY A 111
LEU A 124
LEU A 139
 None
 0.96A 5ycnA-2k77A:
undetectable		 5ycnA-2k77A:
20.71