SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k78'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z11_B_8MOB501_0 (CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6)	2k78	IRON-REGULATED SURFACE DETERMINANT PROTEIN C (Staphylococcus aureus)	5 / 11	PHE A 53 VAL A 72 ILE A 117 GLY A 80 PHE A 104	ZNH A 151 (-3.6A) None ZNH A 151 (-4.0A) None None	1.05A	1z11B-2k78A: undetectable	1z11B-2k78A: 13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z11_C_8MOC501_0 (CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6)	2k78	IRON-REGULATED SURFACE DETERMINANT PROTEIN C (Staphylococcus aureus)	5 / 10	PHE A 53 VAL A 72 ILE A 117 GLY A 80 PHE A 104	ZNH A 151 (-3.6A) None ZNH A 151 (-4.0A) None None	1.04A	1z11C-2k78A: undetectable	1z11C-2k78A: 13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z11_D_8MOD501_0 (CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6)	2k78	IRON-REGULATED SURFACE DETERMINANT PROTEIN C (Staphylococcus aureus)	5 / 10	PHE A 53 VAL A 72 ILE A 117 GLY A 80 PHE A 104	ZNH A 151 (-3.6A) None ZNH A 151 (-4.0A) None None	1.03A	1z11D-2k78A: undetectable	1z11D-2k78A: 13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_G_CLMG221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	2k78	IRON-REGULATED SURFACE DETERMINANT PROTEIN C (Staphylococcus aureus)	5 / 12	SER A 82 TYR A 140 VAL A 119 PHE A 53 ALA A 49	None None None ZNH A 151 (-3.6A) ZNH A 151 (-3.9A)	1.15A	3u9fG-2k78A: undetectable 3u9fH-2k78A: undetectable	3u9fG-2k78A: 20.64 3u9fH-2k78A: 20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F7L_B_ACTB503_0 (AMINE OXIDASE LKCE)	2k78	IRON-REGULATED SURFACE DETERMINANT PROTEIN C (Staphylococcus aureus)	3 / 3	VAL A 72 GLU A 99 ILE A 78	None None ZNH A 151 ( 3.7A)	0.66A	6f7lB-2k78A: undetectable	6f7lB-2k78A: 13.09

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Z11_B_8MOB501_0","CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6","2k78","IRON-REGULATED SURFACE DETERMINANT PROTEIN C","Staphylococcus aureus",5,"PHE A  53;VAL A  72;ILE A 117;GLY A  80;PHE A 104","ZNH A 151 (-3.6A);None;ZNH A 151 (-4.0A);None;None","1.05A","1z11B-2k78A:undetectable","1z11B-2k78A:13.66"],["1Z11_C_8MOC501_0","CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6","2k78","IRON-REGULATED SURFACE DETERMINANT PROTEIN C","Staphylococcus aureus",5,"PHE A  53;VAL A  72;ILE A 117;GLY A  80;PHE A 104","ZNH A 151 (-3.6A);None;ZNH A 151 (-4.0A);None;None","1.04A","1z11C-2k78A:undetectable","1z11C-2k78A:13.66"],["1Z11_D_8MOD501_0","CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6","2k78","IRON-REGULATED SURFACE DETERMINANT PROTEIN C","Staphylococcus aureus",5,"PHE A  53;VAL A  72;ILE A 117;GLY A  80;PHE A 104","ZNH A 151 (-3.6A);None;ZNH A 151 (-4.0A);None;None","1.03A","1z11D-2k78A:undetectable","1z11D-2k78A:13.66"],["3U9F_G_CLMG221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","2k78","IRON-REGULATED SURFACE DETERMINANT PROTEIN C","Staphylococcus aureus",5,"SER A  82;TYR A 140;VAL A 119;PHE A  53;ALA A  49","None;None;None;ZNH A 151 (-3.6A);ZNH A 151 (-3.9A)","1.15A","3u9fG-2k78A:undetectable;3u9fH-2k78A:undetectable","3u9fG-2k78A:20.64;3u9fH-2k78A:20.64"],["6F7L_B_ACTB503_0","AMINE OXIDASE LKCE","2k78","IRON-REGULATED SURFACE DETERMINANT PROTEIN C","Staphylococcus aureus",3,"VAL A  72;GLU A  99;ILE A  78","None;None;ZNH A 151 ( 3.7A)","0.66A","6f7lB-2k78A:undetectable","6f7lB-2k78A:13.09"]]