SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2k8e UPF0339 PROTEIN YEGP
(Escherichia
coli) 		4 / 7 ALA A  88
PHE A  33
ARG A  63
ASN A  65
 None
 1.32A 1t9wA-2k8eA:
undetectable		 1t9wA-2k8eA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 2k8e UPF0339 PROTEIN YEGP
(Escherichia
coli) 		5 / 10 SER A  51
PHE A  31
LEU A  23
GLY A 127
THR A  53
 None
 1.45A 2b8jB-2k8eA:
undetectable		 2b8jB-2k8eA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 2k8e UPF0339 PROTEIN YEGP
(Escherichia
coli) 		4 / 6 TYR A 100
ASN A  85
TYR A  83
GLU A  47
 None
 1.23A 6gneA-2k8eA:
undetectable		 6gneA-2k8eA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 2k8e UPF0339 PROTEIN YEGP
(Escherichia
coli) 		4 / 8 TYR A 100
ASN A  85
TYR A  83
GLU A  47
 None
 1.25A 6gneB-2k8eA:
undetectable		 6gneB-2k8eA:
15.63