SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 2k8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Escherichia
coli) 		4 / 4 THR A  17
GLY A 121
ASP A 120
ALA A 126
 None
 1.20A 1sg9A-2k8iA:
undetectable		 1sg9A-2k8iA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2k8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Escherichia
coli) 		5 / 10 ASP A  24
LEU A  32
ILE A  42
LEU A  45
PHE A 132
 None
 0.98A 4odoA-2k8iA:
14.8		 4odoA-2k8iA:
47.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2k8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Escherichia
coli) 		5 / 10 LEU A  32
LEU A  41
ILE A  42
LEU A  45
PHE A 132
 None
 1.06A 4odoA-2k8iA:
14.8		 4odoA-2k8iA:
47.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2k8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Escherichia
coli) 		5 / 11 GLU A 135
ALA A  12
LEU A  11
LEU A  49
LEU A  41
 None
 1.19A 4wg0I-2k8iA:
undetectable
4wg0J-2k8iA:
undetectable
4wg0K-2k8iA:
undetectable		 4wg0I-2k8iA:
15.00
4wg0J-2k8iA:
15.00
4wg0K-2k8iA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2k8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Escherichia
coli) 		5 / 11 GLU A 135
LEU A  11
LEU A  49
LEU A  45
LEU A  41
 None
 1.17A 4wg0I-2k8iA:
undetectable
4wg0J-2k8iA:
undetectable
4wg0K-2k8iA:
undetectable		 4wg0I-2k8iA:
15.00
4wg0J-2k8iA:
15.00
4wg0K-2k8iA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2k8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Escherichia
coli) 		5 / 12 GLY A  37
SER A  40
VAL A   8
ALA A 142
LEU A   7
 None
 1.03A 5kocA-2k8iA:
undetectable		 5kocA-2k8iA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2k8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Escherichia
coli) 		3 / 3 VAL A 112
GLU A 113
ILE A 109
 None
 0.65A 6f7lB-2k8iA:
undetectable		 6f7lB-2k8iA:
18.30