SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k8v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2I30_A_SALA1100_1 (SERUM ALBUMIN)	2k8v	THIOREDOXIN DOMAIN-CONTAINING PROTEIN 12 (Homo sapiens)	4 / 6	PHE A 74 TYR A 126 GLY A 135 LYS A 137	None	1.47A	2i30A-2k8vA: undetectable	2i30A-2k8vA: 15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O7G_A_ASCA303_0 (PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2)	2k8v	THIOREDOXIN DOMAIN-CONTAINING PROTEIN 12 (Homo sapiens)	4 / 7	HIS A 24 ILE A 45 TYR A 126 PHE A 102	None	1.31A	4o7gA-2k8vA: undetectable 4o7gB-2k8vA: undetectable	4o7gA-2k8vA: 21.72 4o7gB-2k8vA: 21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O7G_B_ASCB304_0 (PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2)	2k8v	THIOREDOXIN DOMAIN-CONTAINING PROTEIN 12 (Homo sapiens)	4 / 6	HIS A 24 ILE A 45 TYR A 126 PHE A 102	None	1.30A	4o7gB-2k8vA: undetectable	4o7gB-2k8vA: 21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CBZ_B_ESTB602_1 (ESTROGEN RECEPTOR)	2k8v	THIOREDOXIN DOMAIN-CONTAINING PROTEIN 12 (Homo sapiens)	5 / 10	MET A 136 LEU A 143 LEU A 103 ILE A 45 HIS A 24	None	1.46A	6cbzB-2k8vA: undetectable	6cbzB-2k8vA: 19.11

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2I30_A_SALA1100_1","SERUM ALBUMIN","2k8v","THIOREDOXIN DOMAIN-CONTAINING PROTEIN 12","Homo sapiens",4,"PHE A  74;TYR A 126;GLY A 135;LYS A 137","None","1.47A","2i30A-2k8vA:undetectable","2i30A-2k8vA:15.04"],["4O7G_A_ASCA303_0","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","2k8v","THIOREDOXIN DOMAIN-CONTAINING PROTEIN 12","Homo sapiens",4,"HIS A  24;ILE A  45;TYR A 126;PHE A 102","None","1.31A","4o7gA-2k8vA:undetectable;4o7gB-2k8vA:undetectable","4o7gA-2k8vA:21.72;4o7gB-2k8vA:21.72"],["4O7G_B_ASCB304_0","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","2k8v","THIOREDOXIN DOMAIN-CONTAINING PROTEIN 12","Homo sapiens",4,"HIS A  24;ILE A  45;TYR A 126;PHE A 102","None","1.30A","4o7gB-2k8vA:undetectable","4o7gB-2k8vA:21.72"],["6CBZ_B_ESTB602_1","ESTROGEN RECEPTOR","2k8v","THIOREDOXIN DOMAIN-CONTAINING PROTEIN 12","Homo sapiens",5,"MET A 136;LEU A 143;LEU A 103;ILE A  45;HIS A  24","None","1.46A","6cbzB-2k8vA:undetectable","6cbzB-2k8vA:19.11"]]