SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2k9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2k9u GAMMA FILAMIN
(Homo
sapiens) 		4 / 8 LEU A  28
ALA A  37
ILE A  63
PHE A 101
 None
 0.77A 1d4sB-2k9uA:
undetectable		 1d4sB-2k9uA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 2k9u GAMMA FILAMIN
(Homo
sapiens) 		5 / 12 SER A  99
ILE A  89
SER A  88
ILE A  53
ASN A  92
 None
 1.02A 2nnhA-2k9uA:
undetectable		 2nnhA-2k9uA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 2k9u GAMMA FILAMIN
(Homo
sapiens) 		5 / 11 ASP A  98
PHE A 101
LEU A  28
PHE A  39
ILE A  89
 None
 1.32A 3o94A-2k9uA:
undetectable		 3o94A-2k9uA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 2k9u GAMMA FILAMIN
(Homo
sapiens) 		5 / 11 ASP A  98
PHE A 101
LEU A  28
PHE A  39
ILE A  89
 None
 1.34A 3o94C-2k9uA:
undetectable		 3o94C-2k9uA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 2k9u GAMMA FILAMIN
(Homo
sapiens) 		5 / 11 ASP A  98
PHE A 101
LEU A  28
PHE A  39
ILE A  89
 None
 1.32A 3o94D-2k9uA:
undetectable		 3o94D-2k9uA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2k9u GAMMA FILAMIN
(Homo
sapiens) 		5 / 8 ALA A  23
ILE A  41
ALA A  18
PHE A  91
LEU A  51
 None
 1.36A 4v1fA-2k9uA:
undetectable
4v1fB-2k9uA:
undetectable		 4v1fA-2k9uA:
23.28
4v1fB-2k9uA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2k9u FILAMIN-BINDING LIM
PROTEIN 1
(Homo
sapiens) 		3 / 3 SER B  12
ALA B  10
VAL B   9
 None
 0.66A 4x20C-2k9uB:
undetectable		 4x20C-2k9uB:
6.40